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Database: UniProt
Entry: Q4DZ99_TRYCC
LinkDB: Q4DZ99_TRYCC
Original site: Q4DZ99_TRYCC 
ID   Q4DZ99_TRYCC            Unreviewed;      2725 AA.
AC   Q4DZ99;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   28-FEB-2018, entry version 75.
DE   SubName: Full=Calcium channel protein, putative {ECO:0000313|EMBL:EAN97848.1};
GN   ORFNames=Tc00.1047053504105.130 {ECO:0000313|EMBL:EAN97848.1};
OS   Trypanosoma cruzi (strain CL Brener).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma;
OC   Schizotrypanum.
OX   NCBI_TaxID=353153 {ECO:0000313|Proteomes:UP000002296};
RN   [1] {ECO:0000313|EMBL:EAN97848.1, ECO:0000313|Proteomes:UP000002296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CL Brener {ECO:0000313|EMBL:EAN97848.1,
RC   ECO:0000313|Proteomes:UP000002296};
RX   PubMed=16020725; DOI=10.1126/science.1112631;
RA   El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA   Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA   Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA   Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA   Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J.,
RA   Darban H., da Silveira J.F., de Jong P., Edwards K., Englund P.T.,
RA   Fazelina G., Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D.,
RA   Hou L., Huang Y., Kindlund E., Klingbeil M., Kluge S., Koo H.,
RA   Lacerda D., Levin M.J., Lorenzi H., Louie T., Machado C.R.,
RA   McCulloch R., McKenna A., Mizuno Y., Mottram J.C., Nelson S.,
RA   Ochaya S., Osoegawa K., Pai G., Parsons M., Pentony M., Pettersson U.,
RA   Pop M., Ramirez J.L., Rinta J., Robertson L., Salzberg S.L.,
RA   Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J., Sisk E.,
RA   Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C., Ward P.N.,
RA   Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA   Andersson B.;
RT   "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT   disease.";
RL   Science 309:409-415(2005).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAN97848.1}.
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DR   EMBL; AAHK01000081; EAN97848.1; -; Genomic_DNA.
DR   RefSeq; XP_819699.1; XM_814606.1.
DR   ProteinModelPortal; Q4DZ99; -.
DR   STRING; 353153.XP_819699.1; -.
DR   PaxDb; Q4DZ99; -.
DR   EnsemblProtists; EAN97848; EAN97848; Tc00.1047053504105.130.
DR   GeneDB; TcCLB.504105.130:pep; -.
DR   GeneID; 3552204; -.
DR   KEGG; tcr:504105.130; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   Proteomes; UP000002296; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002296};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    392    413       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    448    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    487    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    597    620       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1062   1081       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1101   1121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1128   1146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1182   1206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1226   1249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1269   1294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1795   1814       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1826   1846       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1866   1885       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1923   1943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2030   2054       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2106   2127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2139   2158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2229   2258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2323   2344       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      355    627       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1070   1301       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1794   2047       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2104   2349       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2362   2420       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED     2619   2642       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2725 AA;  307293 MW;  0F0BBEC420EC697C CRC64;
     MSGVPPAYPV DSNIGVPNAH TQQRLPASGS QSNTSSRVII GGVAPPTSTG RPHLPLPLPP
     VKGAASQPPL TGTGSVPAPG HPPMGRLTPL QHRTLDGTEA QPGARPSPPP RLPMNSSTTQ
     PTEASGAAEN GDGQSSAAGG LPTFHATINP LSPISQQEQL RQQRQHTPSR KTTDRAGTSS
     ARSRKTMTPA SQQGTRPQSA ISGEETVEVL CPLPTQTRPV ERFFVEFNPG AIVGNGRDDN
     AMYEEALLFD RLAEYTEDDS FFSSGSSVLE EDPRRLQKDI FRERAVRSVY DTLNLRALTG
     GRTPQELEDK NRENAGWMYQ VHRRAIALHH SSFFVFPAGM KARVVTYNVL HHWLMELMIL
     LIILGYSIFT ASWSRYGAPE FEKPDFMVFA DFLYTILYGI EIIARLFASG CILHSRAYFR
     SPWHWLDTAV FVLMIMNCTQ WRDLWNFTAF RLIRIIKACT YLPLPIRMKI IAKSVLRSTC
     KLFQTSIILV YALFFFALLG LQLFRGVLHY RCVNSLTGAA TSQLCRPEAT GHYWFYWGHV
     CDPGYICISD GFPNPNYDFR SFDDVGHALL STFQIMTFQG WTSLLQETND AVTTLAFLYY
     FFTILLCAWL IPGLFIGVFI EKIEKTSRLF EQKQLELFDA MLLEQRQRLT EAIKLRDFVE
     RDECGRLRGH LAEAAPEDTS YPTLRVNSAS SNGKFPESGS FNSRNSERNT SVVTGSSGAA
     KKRTKWTDEQ RVQLHLSLTR QRDIAEQGER RRRVIFKVDK KETDHTNGNF EMSSVSTNTT
     NNMGGGDFAL GGRVGTVQHH PLTYTIGAAH GTRLPLAVRL ENEQERLQFL KYYQQAEEAD
     DTTLQGGLTR GSRGVDGSTN NNMNSSHLSH SHPMRRGVGH GDEMGSDIIT IRESAGVIPN
     RRSATTRGNT SGASTSLRTS TAAAAALNGS AGGVAQSQEI LIHDPEGGDF RYAKTFGQSW
     GIIRNILHMF TEGCPRILTQ YLWEHRRMQT RFGLLPLNYV NKYEEAALRK LRQKRARRGK
     LILKNNRIED DGTDDYSEPE EPANEDQEYL GKLSPIRMAK NIVENAPVTL FSGIMLFLVF
     ANGVFNASRH YGQPVYWEDG LFIAGVCFTS LFMLELIIRF IVLGPGPFVC DFINVICVIV
     TVIGFFELGF GHSNTITVLN WVRFLRLFRI APFAPMRRVT RVFLLGFQDI VYALILFSVY
     MFMWILTGMS FFGGRFGRLT TQNDDYATIG FFDTFSHATF AVAQAFSYVR DEWLYLSWDG
     MRVRGGYTII YFLAVVFVAF IFRYLFIAVF AWAWQQQEER EDYVLHTTSK GGHQNRGGPR
     LHWFDFTVWR SFKHIHGGFE RRDVAPDEVF HLNQDMRRQL RIAEAKERFT RESMTRRGFS
     ADPQTIFSDS FSTNGNVASY GMPSSAPPLM LAPQFVNVGG QLQRQMSMPS TFDEPPPHPA
     QAPISRFQAE NAQLRFARRY SAVPATPYRG VAEELNGAHF LPVTSTPSDQ ALHNSNGSVA
     DTAAETEGLS HQIGGRASGL YGVHGSSNLP NEHHSSVTGY FTTLGYDKSG EKKNGEAMEN
     YQQSSENEEN GDPENSVVDG GGGGGGSGGV VYEHVLLPGP RLRYKHIMVG RHRRVFERCL
     DCNVHKQIPL RAPPNVQQRT ADELHAEHCH MAAVRSSRQL VLNTIIGYVR LQKELGGPPT
     REAVETVLGQ AWSCGMLLFE SIEYLSCADI ELREYRTWDR TLEALQLQQW LIGLHLGEEQ
     VGRATLAYIL AHQKTQERVA THSSFHRSWR DRSFFIFSPS HPARRFLTAI VESKWFEWFI
     LAVIFAASIC LCFYSPEDED RTSKKYLALH ILDDIFAIIF AVEMVLKWIS MGVVLDCHVA
     YFWHRWNTFD CFITIISLIA IAPKYSHFRF LKVMRCFRIL GPMRYCRFNK ELSKLALTMW
     DSVPTLVNVL LLFLLNYIVW SILALRLFMG LTHSCTSHAF SNKTSCEEAG AMWLGPQRNF
     DNFYESLLTM FEVSTGSRWL DVIYTGVDGW SMEFEPIYNR HPSKGLFFVA YYYVSHFVLF
     SLFVASLIYC YLLAKNAAEG VTDITFEHQL WLRMQRMILR LRPRVELVPL GNCLSRFLHR
     IVIHPAFELV MAGILLCNMI TMSLYWYGNS SRQEKALDIL EHLWVAFFTL EILMKLTAHG
     LRAFSRYSFC FQVFVTSLSY LQIGLNTTVG NHVPFNVNTL RLLHLGRMLK LVDFLVPVRH
     HLHLLHEALL LSASSLVNVT LILALAVFVF AVLGMHFIGP VVPVAGQYID DTYNNFRTFP
     NALMMIFRLA TLEDWVSMLR SSMSDGNNCP ISDCKTTNWA PVFYVPIVIC FALMIVNLYL
     AVVVDHYVTV VRMKASVARI NDLRRFRDLW SARDPNATLL LRTRKLPELL EALRPPLGLS
     SRKNRAELLR LLREYDIPDH GGKVHYYEVL LPLARRVLAM AFSEDEIDDG VKFEAVWRLS
     ESSLRALPTV LVHHSSATAA QHFAASYVQA AYRRDKACRK LHEMRANCWR EARRICDELG
     LPYKDYGFGD VSLEDEDPRN EAARRGLLNE STNEEKKQKN AADVTAAAAF AAAGRSESMT
     TDSNESSGKP APAARLPGLY QPAIDEKEKR FGPDVPHAVR RHETRSDKLR RKEEERQQQQ
     QQDPMDRQPS VPPAPRSTAQ RNQSIDYQPP LGTDPSEWLQ NEMGRRMSGA GAGTLSSANH
     TGAGGGASPT KATAPPSSEG LDGNV
//
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