ID Q4E175_TRYCC Unreviewed; 883 AA.
AC Q4E175;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Heat shock protein 70 (HSP70), putative {ECO:0000313|EMBL:EAN98515.1};
GN ORFNames=Tc00.1047053511585.70 {ECO:0000313|EMBL:EAN98515.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98515.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98515.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98515.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98515.1}.
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DR EMBL; AAHK01000053; EAN98515.1; -; Genomic_DNA.
DR RefSeq; XP_820366.1; XM_815273.1.
DR AlphaFoldDB; Q4E175; -.
DR SMR; Q4E175; -.
DR STRING; 353153.Q4E175; -.
DR PaxDb; 353153-Q4E175; -.
DR EnsemblProtists; EAN98515; EAN98515; Tc00.1047053511585.70.
DR GeneID; 3553002; -.
DR KEGG; tcr:511585.70; -.
DR eggNOG; KOG0100; Eukaryota.
DR InParanoid; Q4E175; -.
DR OMA; FEEWCRP; -.
DR OrthoDB; 152360at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd10230; HYOU1-like_NBD; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR45639:SF3; HYPOXIA UP-REGULATED PROTEIN 1; 1.
DR Pfam; PF00012; HSP70; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Stress response {ECO:0000313|EMBL:EAN98515.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 659..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 96944 MW; E8DAE0F2E19DEFEA CRC64;
MKMEGEQWMG GVAGVCRGKA SHFLKATSCS TTRSPLLLFC IILLLTGTPF MSFLVEAHHI
LAVDLGVDWA KAATLGGGSG ASLIPTIVLN DQANRKSPQC IAFRFLPYDT DDILQRVERF
FSEQAQSLEP RFPDQVVCGP SLLAGRGVSR VVTDGNNTGG VTQGSNNKDA LSLDELASLT
FSVVPHSSRD KVAVRILGGK NKSVLEFSTE ELIGMFFAYL KRIAERGLNG EPLRHLVVTV
SAHASLAQRQ TFVDAAAVAG LRAVRLVHGT TAAAVQLAHL NIEQFFSSAR EKGPKYIMVY
DMGGRRTEVA VYEFAPSRQR LGTITLRTAI VNNTLGGRAF DRCIARYIER EHFPKARPKA
IEPVLGVSSP AARKAAVSLM RAVQNARERL SVNQEAPVVV QGVQEGDSGD FTTIISRAVF
EQECAHLFDE AVRLRDEAIA QTKGIVSSVR ELTRFEMIGG ATRMPKLLER LSDGYGRAVD
RTLNSDEAAV VGASYMGAAR ANIPIRGFAV VEPLMNDVWF SLTPSLQDPR DAAAPPRDST
RHLIFPKGST ILPAVRSLQL KNRTADFTLT LEDESGHFTR ATFIRGVNES IMAAQLLPQS
FRASDGAGKK RRERLSLEHT EVMLEVTATE SGIPFVSNAY LHATYLKVTV AKEPTDTVQN
ESNAGSAAGE NATDAEAPNG TEKSSKPQQP DEYPGEEQEE QQQRDLGAEE KWDERQEKAA
EEEGEEERKE NHNVSDQASE KDSNASEATA PRAEDTSAEK EIVERVVRSF PLRLVSVPLS
VGVNLNKLEA AAARDRLYAF QRVDDERLMR SALRNDIETL ILHYKSLDAW DKAVENEGEA
NWREVVKEVE QWLDDTSDNV EISELQRQQQ RMNKLQIGGA TTG
//
