ID Q4E283_TRYCC Unreviewed; 894 AA.
AC Q4E283;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98890.1};
GN ORFNames=Tc00.1047053510275.350 {ECO:0000313|EMBL:EAN98890.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98890.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98890.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98890.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98890.1}.
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DR EMBL; AAHK01000037; EAN98890.1; -; Genomic_DNA.
DR RefSeq; XP_820741.1; XM_815648.1.
DR AlphaFoldDB; Q4E283; -.
DR SMR; Q4E283; -.
DR PaxDb; 353153-Q4E283; -.
DR EnsemblProtists; EAN98890; EAN98890; Tc00.1047053510275.350.
DR GeneID; 3553505; -.
DR KEGG; tcr:510275.350; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E283; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..441
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 95693 MW; 80BA8A66D29634F2 CRC64;
MHSRVAAVKA PRTHNRYRVT GSSGRRREGG ESEPQRPIMS RRVFTSAVLL LLVVMMCCGS
AAASASEPSK RKLFVWRDVR DGETVSSLCV PSLLKVGSDV FAVAEAQDTK KEEGDFTGIA
SELLEWNGEQ KKEELDKTKL KTQVLEECPS DKANCASQIV AQASFERGTK VYLARPTTVV
QGSDIYMLAG IYNLDAADNT SAYWGLLLSR GNVSGDEKSK KRIHWNHIDA LQSISNMQKE
ESLTDLIGGG GSGVKMNDGT LVFPVEGIKS NGAAGVTDTV SLVIHSTGTE GWKLSKDVSA
GGCSDPSVVE WEDKKLMMMT ACDDGRRRVY ESGDKGDSWT EALGTLSRVW GNKHTGPEKG
VGSGFITAKI DNRDVMLVTL PVYSKEKEKE ENGKGRLHLW LTDNTHIADI GPVSEKEEDV
AASSLLYEST ESKEELIALY EKKKGGDKDT SLGMASVRLT AQLQRVKELL ATWNEVDERI
SQLCATLLAQ EDTSPDNPCR STFKITDGLV GFLSGNFSEN TWMDEYLGVN ATVHNKGGAA
KAEDGVKFQG AWAEWPVGKQ GENQLYHFAN YKFTLVATVS VHGEPEEDTP IPFLGAKMTG
AGNSVFLGLS YGKEKKWQLL CGVETKSKDR SVFWGPKTKD HVVILLRNGT QGSAYVDGKR
VGDVPCALAN TDSKDISYFY IGGDGDKTRK QEDVPVTVTN VLLYNRPLDE AEIGALNPNK
DPIQLLEKEA AKPSTVSSDS VVPPSPLVTA TAQQTETPST PAGTQLTEQG QSMGSSKGAG
SGGASKSAVS TLSTPSAEED SLVQSASGTS PDGTQTVGGG FTADGEPTME TREGGTNGQE
EEVNKQVGDV NATALSSSLG NVSQGNNSDT GTVCESGLVP SLLLLLGLWG FAAL
//
