ID Q4E2C9_TRYCC Unreviewed; 782 AA.
AC Q4E2C9;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN98944.1};
GN ORFNames=Tc00.1047053509979.320 {ECO:0000313|EMBL:EAN98944.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98944.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98944.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98944.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98944.1}.
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DR EMBL; AAHK01000035; EAN98944.1; -; Genomic_DNA.
DR RefSeq; XP_820795.1; XM_815702.1.
DR AlphaFoldDB; Q4E2C9; -.
DR SMR; Q4E2C9; -.
DR PaxDb; 353153-Q4E2C9; -.
DR EnsemblProtists; EAN98944; EAN98944; Tc00.1047053509979.320.
DR GeneID; 3553573; -.
DR KEGG; tcr:509979.320; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4E2C9; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..452
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 82806 MW; 87946CBD6D2DDFC7 CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRTEGR ESEQRRPNMS WHVFTSAVLL LLVVMMCCGP
CGGAALAENS ASGTAQGQGN SPSSSLGWRD AKGETLSLLR VPSLVEVNGG VFAVAEAQLK
EGEGDFFTGI ASELLEWTDK ESKELDTNKL KTQVLEECPA GNNSCASQTG AQEASASQSR
TKVRVSRPTT VVNGSRIYMV AGNYSFEVTG TAGNTAAAAK WGFFGSVGRV SNDGSSGKKF
YWKDAFVISL TDFEKHESLT RLIGGGGSGV KMKDGTIVFP VEGTKKDGKA VSLIIYSSAN
ESGNLSKGMS DGGCSDPSVV EWKEGKLMMM TACDDGRRRV YESGDKGDSW TEALGTLSRV
WGNKHKGNEK GVGSGFSTAT IENRNVMLVT VPVYSNRKGK ERAELHLWLT DNTHIADIGP
VSGDDDVAAS SLLYKSAGSG NDNNENLIAL YEKKKGGGES SLGMVSVRLT AQLKRVKEVV
ATWKEVDGRV SQLCPSKSPA KNPSTGNDCS AVKITDGLVG FLSKNFSGNT WRDEYLGVDA
TVKKGTNGVA TGYGDGVTFR GAWAEWPVGS QGENQLYYFS NHDFTLVATL SVHGEPKGDT
PIALMGATMN DKNPVLLGLS YDKEGKWQVL CGGKTTKELR SNWEPGTTHQ VAIVLRNGKQ
GSAYVDGQRV GDASCELKNT DSKGISHFYI GGDGGSAGRK EGVPVTVTNV LLYNRPLDDN
EIRVLNANKI SIPKLTDLKT LAAGATGEGT ARDGGAHGGS TVCGGGLLPL LLLLGLWGIA
AS
//
