ID Q4E3T3_TRYCC Unreviewed; 685 AA.
AC Q4E3T3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE SubName: Full=DNA polymerase sigma, putative {ECO:0000313|EMBL:EAN99413.1};
GN ORFNames=Tc00.1047053506401.100 {ECO:0000313|EMBL:EAN99413.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN99413.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN99413.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN99413.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN99413.1}.
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DR EMBL; AAHK01000020; EAN99413.1; -; Genomic_DNA.
DR RefSeq; XP_821264.1; XM_816171.1.
DR AlphaFoldDB; Q4E3T3; -.
DR SMR; Q4E3T3; -.
DR STRING; 353153.Q4E3T3; -.
DR PaxDb; 353153-Q4E3T3; -.
DR EnsemblProtists; EAN99413; EAN99413; Tc00.1047053506401.100.
DR GeneID; 3554117; -.
DR KEGG; tcr:506401.100; -.
DR eggNOG; KOG1906; Eukaryota.
DR InParanoid; Q4E3T3; -.
DR OMA; TIQKERC; -.
DR OrthoDB; 21395at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0050265; F:RNA uridylyltransferase activity; IEA:UniProt.
DR GO; GO:0071076; P:RNA 3' uridylation; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR PANTHER; PTHR23092:SF47; POLYMERASE SIGMA, PUTATIVE-RELATED; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 294..367
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 462..528
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 74967 MW; EE42FB7EE6CEECFF CRC64;
MRGGAMKRRR RVVVSQGAVV TSDDTPTCTD GKHNNKLNNN TDDYDKKDND NTTSLNGTPN
VPNSSSPAPA CSLFSRFQQR SSDFSGEWLM MEEADVPLVP PISHELAEKL RQHQGTIQKE
RCGAAAPGRK DGKEALHTTP AAGTATLSVG GRETSDVEDE EHVPQDVGVK KLLGGGDDGG
EGVGIHGDYL SFLPPSSALS DVAQSDLQAT LTVQEGRDGR VVSKSSSTQS LRSRSKEFLL
TRQRVVPLWS VERYTTHGGY ASNAAIALHQ EVCDFVKYLR PSEAEIFMRR IIAMEVRTIA
KRLWPDCEPI VFGSMSTGLL LPLSDLDMSI LKVPVTTEEA LTALAREISR EGLCHAAYPQ
LILKTKVPLV KFQHRLSLLD VDVSINAEDG QRNSAIVADM LCSFPEARPL IVLVKYFLQQ
RGMHEPYHGG LGSFATTLLV ISFLQNHPIY TERPEERAYT GLGTLLVDFF RYYGMYFNYH
QCGISLLDGG RYFLRGETSA LTPSSPTGQS SSQGLSQVMI EDPGCVQNNA ASSLRIFHVI
TSVFTHAYMA LTALFDAPVG VEQEFLPDAM EIARRPTLLS RILHVDGPSV ARRQFIDAAY
DGLLQDPAQK EKLMAMTTAS SMEEMVAIRK VQLQGGASWN GSTNIQERKR PRSGSGSGDS
SNTSSSSTSS NSSSACVAFR RHRRR
//