GenomeNet

Database: UniProt
Entry: Q4EDJ3_9RICK
LinkDB: Q4EDJ3_9RICK
Original site: Q4EDJ3_9RICK 
ID   Q4EDJ3_9RICK            Unreviewed;       331 AA.
AC   Q4EDJ3;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-NOV-2023, entry version 81.
DE   RecName: Full=Delta-aminolevulinic acid dehydratase {ECO:0000256|ARBA:ARBA00020771, ECO:0000256|RuleBase:RU000515};
DE            EC=4.2.1.24 {ECO:0000256|ARBA:ARBA00012053, ECO:0000256|RuleBase:RU000515};
GN   ORFNames=EA652_0088 {ECO:0000313|EMBL:QEF49803.1};
OS   Wolbachia endosymbiont of Drosophila ananassae.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia.
OX   NCBI_TaxID=307502 {ECO:0000313|EMBL:QEF49803.1, ECO:0000313|Proteomes:UP000321156};
RN   [1] {ECO:0000313|EMBL:QEF49803.1, ECO:0000313|Proteomes:UP000321156}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W2.1 {ECO:0000313|EMBL:QEF49803.1,
RC   ECO:0000313|Proteomes:UP000321156};
RA   Gasser M.T., Chung M., Bromley R.E., Nadendla S., Dunning Hotopp J.C.;
RT   "Complete Genome of Wolbachia endosymbiont, wAna, from Drosophila
RT   ananassae.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen;
CC         Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00001227,
CC         ECO:0000256|RuleBase:RU000515};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004694}.
CC   -!- SUBUNIT: Homooctamer. {ECO:0000256|RuleBase:RU000515}.
CC   -!- SIMILARITY: Belongs to the ALAD family. {ECO:0000256|ARBA:ARBA00008055,
CC       ECO:0000256|RuleBase:RU004161}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP042904; QEF49803.1; -; Genomic_DNA.
DR   RefSeq; WP_006280460.1; NZ_NSDT01000043.1.
DR   KEGG; wea:EA652_0088; -.
DR   OrthoDB; 9805001at2; -.
DR   UniPathway; UPA00251; UER00318.
DR   Proteomes; UP000321156; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004655; F:porphobilinogen synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04823; ALAD_PBGS_aspartate_rich; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR001731; ALAD.
DR   InterPro; IPR030656; ALAD_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   PANTHER; PTHR11458; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   PANTHER; PTHR11458:SF0; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   Pfam; PF00490; ALAD; 1.
DR   PIRSF; PIRSF001415; Porphbilin_synth; 1.
DR   PRINTS; PR00144; DALDHYDRTASE.
DR   SMART; SM01004; ALAD; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00169; D_ALA_DEHYDRATASE; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000515};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU000515}.
SQ   SEQUENCE   331 AA;  36736 MW;  D42B56D509603364 CRC64;
     MFNFPNTRLR RRRSSKWVRN LTSENSLSVN DLVLPLFVHD REETTEPISG LPDVKCYSID
     GLVSIVKEAK DLGINAVAIF PVVDSKLKSE NAEEAYNSDN LICRAICAVK LKVPEIGIIA
     DIALDPYTIH GHDGILKDNQ MDVENDETIS VLCKQALALA KAGCDIVAPS DMMDGRIGRI
     RKSLDDNNFQ DVLILSYAVK YCSSFYAPFR QVVGSCGLSH SIDKSGYQMD YKNAREAMCE
     IEMDINEGAD FIMIKPGMPY LDIIKTASDK FNFPIFAYQV SGEYAMIKAA ANNSWLDYDK
     VIYESLIGFK RAGASAIFTY AALDIAKNLS A
//
DBGET integrated database retrieval system