ID Q4FTF9_PSYA2 Unreviewed; 345 AA.
AC Q4FTF9;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Methionine synthase (B12-independent) {ECO:0000313|EMBL:AAZ18699.1};
DE EC=2.1.1.14 {ECO:0000313|EMBL:AAZ18699.1};
GN Name=metE {ECO:0000313|EMBL:AAZ18699.1};
GN OrderedLocusNames=Psyc_0846 {ECO:0000313|EMBL:AAZ18699.1};
OS Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=259536 {ECO:0000313|EMBL:AAZ18699.1, ECO:0000313|Proteomes:UP000000546};
RN [1] {ECO:0000313|EMBL:AAZ18699.1, ECO:0000313|Proteomes:UP000000546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17307 / VKM B-2377 / 273-4
RC {ECO:0000313|Proteomes:UP000000546};
RX PubMed=20154119; DOI=10.1128/AEM.02101-09;
RA Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A., Ivanova N.,
RA Bergholz P.W., Di Bartolo G., Hauser L., Land M., Bakermans C.,
RA Rodrigues D., Klappenbach J., Zarka D., Larimer F., Richardson P.,
RA Murray A., Thomashow M., Tiedje J.M.;
RT "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive
RT Siberian permafrost bacterium, reveals mechanisms for adaptation to low-
RT temperature growth.";
RL Appl. Environ. Microbiol. 76:2304-2312(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00009553}.
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DR EMBL; CP000082; AAZ18699.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4FTF9; -.
DR STRING; 259536.Psyc_0846; -.
DR KEGG; par:Psyc_0846; -.
DR eggNOG; COG0620; Bacteria.
DR HOGENOM; CLU_040013_3_0_6; -.
DR Proteomes; UP000000546; Chromosome.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR016456; Met_Synthase_cat.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR PIRSF; PIRSF005632; Met_synth_catalytic_prd; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:AAZ18699.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000546};
KW Transferase {ECO:0000313|EMBL:AAZ18699.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 8..336
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
SQ SEQUENCE 345 AA; 38822 MW; 3F314CB0B508BB36 CRC64;
MNDMKLLLPT STAGSLPKPS WLAEPEKIWS PWALEGEQLI EAKQDALRVS LHEQLHAGID
IVSDGEQTRQ HFVTTFIEHL DGVDFEKRET VRIRNRYDAS VPSVVGAVSR QKPVFVDDAK
FLRQQTDQPI KWALPGPMTM IDTLYDGHYK SREKLAWEFA KILNQEAREL EAAGVDIIQF
DEPAFNVFFD DVNDWGIATL ERAIEGLKCE TAVHICYGYG IKANNDWKKT LGSEWRQYEQ
AFPKLQQSNI DIVSLECQNS HVPMDLIELI RGKKVMIGAI DVATNTIETP EEVANTLRKA
LQFVDADKLY PSTNCGMAPL SRQVAQGKLK ALSAGAKIVR QELTA
//
