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Database: UniProt
Entry: Q4FUV6
LinkDB: Q4FUV6
Original site: Q4FUV6 
ID   RNC_PSYA2               Reviewed;         265 AA.
AC   Q4FUV6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   14-MAY-2014, entry version 55.
DE   RecName: Full=Ribonuclease 3;
DE            EC=3.1.26.3;
DE   AltName: Full=Ribonuclease III;
DE            Short=RNase III;
GN   Name=rnc; OrderedLocusNames=Psyc_0333;
OS   Psychrobacter arcticus (strain DSM 17307 / 273-4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Moraxellaceae; Psychrobacter.
OX   NCBI_TaxID=259536;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17307 / 273-4;
RX   PubMed=20154119; DOI=10.1128/AEM.02101-09;
RA   Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A.,
RA   Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M.,
RA   Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F.,
RA   Richardson P., Murray A., Thomashow M., Tiedje J.M.;
RT   "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive
RT   Siberian permafrost bacterium, reveals mechanisms for adaptation to
RT   low-temperature growth.";
RL   Appl. Environ. Microbiol. 76:2304-2312(2010).
CC   -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC       of primary rRNA transcript to yield the immediate precursors to
CC       the large and small rRNAs (23S and 16S). Also processes some
CC       mRNAs, and tRNAs when they are encoded in the rRNA operon (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC       phosphomonoester.
CC   -!- COFACTOR: Mg(2+) (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC   -!- SIMILARITY: Contains 1 RNase III domain.
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DR   EMBL; CP000082; AAZ18202.1; -; Genomic_DNA.
DR   RefSeq; YP_263636.1; NC_007204.1.
DR   ProteinModelPortal; Q4FUV6; -.
DR   STRING; 259536.Psyc_0333; -.
DR   EnsemblBacteria; AAZ18202; AAZ18202; Psyc_0333.
DR   GeneID; 3515050; -.
DR   KEGG; par:Psyc_0333; -.
DR   PATRIC; 23054953; VBIPsyArc98534_0413.
DR   eggNOG; COG0571; -.
DR   HOGENOM; HOG000246809; -.
DR   KO; K03685; -.
DR   OMA; IDNVNDQ; -.
DR   OrthoDB; EOG6T1WVS; -.
DR   BioCyc; PARC259536:GI3A-344-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRNA-bd_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   PANTHER; PTHR11207; PTHR11207; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   TIGRFAMs; TIGR02191; RNaseIII; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW   Metal-binding; mRNA processing; Nuclease; RNA-binding;
KW   rRNA processing; rRNA-binding; tRNA processing.
FT   CHAIN         1    265       Ribonuclease 3.
FT                                /FTId=PRO_0000228570.
FT   DOMAIN       34    157       RNase III.
FT   DOMAIN      185    256       DRBM.
FT   ACT_SITE     74     74       Potential.
FT   ACT_SITE    146    146       By similarity.
FT   METAL        70     70       Magnesium (By similarity).
FT   METAL       143    143       Magnesium (By similarity).
FT   METAL       146    146       Magnesium (By similarity).
SQ   SEQUENCE   265 AA;  30015 MW;  AFDCB629D99CF43F CRC64;
     MKPTSQYPQA VPNPPKNSLS DDTLVISSEF IQRLAVLTRK LGYVFNDLSL AKLALTHRSF
     DSKKNYERLE FLGDALLGMI VGEALYHRYP TQNEGRLTRM RATLVRQESL VIIAQNLELS
     NQLILGVGER KGGGRNRASI LADAVESLIG AIYLDSQDMN ITRECVLSWY GDLIDNVNDQ
     KALKDAKSRL QEWLQSKQFD LPHYELMETR GNAPHQLFVV RCQVNIINCP DITESGESRR
     IAEQKAAELM INQLHKLPGV PKKRR
//
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