ID RNC_PSYA2 Reviewed; 265 AA.
AC Q4FUV6;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 29-MAY-2013, entry version 49.
DE RecName: Full=Ribonuclease 3;
DE EC=3.1.26.3;
DE AltName: Full=Ribonuclease III;
DE Short=RNase III;
GN Name=rnc; OrderedLocusNames=Psyc_0333;
OS Psychrobacter arcticus (strain DSM 17307 / 273-4).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Moraxellaceae; Psychrobacter.
OX NCBI_TaxID=259536;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17307 / 273-4;
RX PubMed=20154119; DOI=10.1128/AEM.02101-09;
RA Ayala-del-Rio H.L., Chain P.S., Grzymski J.J., Ponder M.A.,
RA Ivanova N., Bergholz P.W., Di Bartolo G., Hauser L., Land M.,
RA Bakermans C., Rodrigues D., Klappenbach J., Zarka D., Larimer F.,
RA Richardson P., Murray A., Thomashow M., Tiedje J.M.;
RT "The genome sequence of Psychrobacter arcticus 273-4, a psychroactive
RT Siberian permafrost bacterium, reveals mechanisms for adaptation to
RT low-temperature growth.";
RL Appl. Environ. Microbiol. 76:2304-2312(2010).
CC -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC of primary rRNA transcript to yield the immediate precursors to
CC the large and small rRNAs (23S and 16S). Also processes some
CC mRNAs, and tRNAs when they are encoded in the rRNA operon (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC phosphomonoester.
CC -!- COFACTOR: Mg(2+) (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC -!- SIMILARITY: Contains 1 RNase III domain.
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DR EMBL; CP000082; AAZ18202.1; -; Genomic_DNA.
DR RefSeq; YP_263636.1; NC_007204.1.
DR ProteinModelPortal; Q4FUV6; -.
DR STRING; 259536.Psyc_0333; -.
DR EnsemblBacteria; AAZ18202; AAZ18202; Psyc_0333.
DR GeneID; 3515050; -.
DR KEGG; par:Psyc_0333; -.
DR PATRIC; 23054953; VBIPsyArc98534_0413.
DR eggNOG; COG0571; -.
DR HOGENOM; HOG000246809; -.
DR KO; K03685; -.
DR OMA; IDNVNDQ; -.
DR ProtClustDB; PRK00102; -.
DR BioCyc; PARC259536:GI3A-344-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:HAMAP.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:HAMAP.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:HAMAP.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1520.10; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR HAMAP; MF_00104; RNase_III; 1; -.
DR InterPro; IPR001159; Ds-RNA-bd.
DR InterPro; IPR014720; dsRNA-bd-like_dom.
DR InterPro; IPR011907; RNase_III.
DR InterPro; IPR000999; RNase_III_dom.
DR PANTHER; PTHR11207; PTHR11207; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00535; RIBOc; 1.
DR SUPFAM; SSF69065; RNase_III; 1.
DR TIGRFAMs; TIGR02191; RNaseIII; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW Metal-binding; mRNA processing; Nuclease; RNA-binding;
KW rRNA processing; rRNA-binding; tRNA processing.
FT CHAIN 1 265 Ribonuclease 3.
FT /FTId=PRO_0000228570.
FT DOMAIN 34 157 RNase III.
FT DOMAIN 185 256 DRBM.
FT ACT_SITE 74 74 Potential.
FT ACT_SITE 146 146 By similarity.
FT METAL 70 70 Magnesium (By similarity).
FT METAL 143 143 Magnesium (By similarity).
FT METAL 146 146 Magnesium (By similarity).
SQ SEQUENCE 265 AA; 30015 MW; AFDCB629D99CF43F CRC64;
MKPTSQYPQA VPNPPKNSLS DDTLVISSEF IQRLAVLTRK LGYVFNDLSL AKLALTHRSF
DSKKNYERLE FLGDALLGMI VGEALYHRYP TQNEGRLTRM RATLVRQESL VIIAQNLELS
NQLILGVGER KGGGRNRASI LADAVESLIG AIYLDSQDMN ITRECVLSWY GDLIDNVNDQ
KALKDAKSRL QEWLQSKQFD LPHYELMETR GNAPHQLFVV RCQVNIINCP DITESGESRR
IAEQKAAELM INQLHKLPGV PKKRR
//
