ID   Q4G654_9REOV            Unreviewed;       175 AA.
AC   Q4G654;
DT   30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2005, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=NSP4 {ECO:0000313|EMBL:AAR18292.1};
DE   Flags: Fragment;
OS   Human rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus; Rotavirus A.
OX   NCBI_TaxID=10941 {ECO:0000313|EMBL:AAR18292.1};
RN   [1] {ECO:0000313|EMBL:AAR18292.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A_G2_222 {ECO:0000313|EMBL:AAR18292.1};
RA   Szabo Zs., Matson D.O., Afflerbach C., Campos F., Berke T., Pickering L.K.,
RA   Ruiz-Palacios G.;
RT   "Sequence Differences of Rotavirus NSP4 Genes Between Strains From Human
RT   Symptomatic and Asymptomatic First Infections.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY353748; AAR18292.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          85..112
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         175
FT                   /evidence="ECO:0000313|EMBL:AAR18292.1"
SQ   SEQUENCE   175 AA;  20409 MW;  D019DD889EBD9B5F CRC64;
     MEKLTDLNYT LSVITLMNNT LHTILEDPGM AYFPYIASVL TVLFTLHKAS IPTMKIALKT
     SKCSYKVVKY CIVTIFNTLL TLAGYKEQIT TKDEIEKQMD RVVKEMRRQL EMIDKLTTRE
     IEQVELLKRI YDKLMVRSTG EIDMTKEINQ KNVRTLEEWE DGKNPYEPKE VTATM
//