ID Q4GYS4_TRYB2 Unreviewed; 1024 AA.
AC Q4GYS4;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Pentacotripeptide-repeat region of PRORP domain-containing protein {ECO:0000259|Pfam:PF17177};
GN ORFNames=TB927.1.2990 {ECO:0000313|EMBL:CAJ16495.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:CAJ16495.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:CAJ16495.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:CAJ16495.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=12907729; DOI=10.1093/nar/gkg674;
RA Hall N., Berriman M., Lennard N.J., Harris B.R., Hertz-Fowler C.,
RA Bart-Delabesse E.N., Gerrare C.S., Atkin R.J., Barron A.J., Bowman S.,
RA Bray-Allen S.P., Bringaud F., Clark L.N., Corton C.H., Cronin A.,
RA Davies R., Doggett J., Fraser A., Gruter E., Hall S., Harper A.D.,
RA Kay M.P., Leech V., Mayes R., Price C., Quail M.A., Rabbinowitch E.,
RA Reitter C., Rutherford K., Sasse J., Sharp S., Shownkeen R., Macleod A.,
RA Taylor S., Tweedie A., Turner C.M.R., Tait A., Gull K., Barrell B.,
RA Melville S.E.;
RT "The DNA sequence of chromosome I of an African trypanosome: gene content,
RT chromosome organisation, recombination and polymorphism.";
RL Nucleic Acids Res. 31:4864-4873(2003).
RN [2] {ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SIMILARITY: Belongs to the PPR family. P subfamily.
CC {ECO:0000256|ARBA:ARBA00007626}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL929603; CAJ16495.1; -; Genomic_DNA.
DR RefSeq; XP_001218997.1; XM_001218996.1.
DR AlphaFoldDB; Q4GYS4; -.
DR STRING; 185431.Q4GYS4; -.
DR PaxDb; 5691-CAJ16495; -.
DR GeneID; 4357368; -.
DR KEGG; tbr:TB927.1.2990; -.
DR VEuPathDB; TriTrypDB:Tb927.1.2990; -.
DR eggNOG; KOG4197; Eukaryota.
DR InParanoid; Q4GYS4; -.
DR OMA; WGVRLWR; -.
DR OrthoDB; 168819at2759; -.
DR Proteomes; UP000008524; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0005763; C:mitochondrial small ribosomal subunit; IDA:GeneDB.
DR GO; GO:0005739; C:mitochondrion; IDA:GeneDB.
DR GO; GO:0004526; F:ribonuclease P activity; IBA:GO_Central.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR033443; PPR_long.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR13547:SF1; MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR13547; UNCHARACTERIZED; 1.
DR Pfam; PF01535; PPR; 1.
DR Pfam; PF13812; PPR_3; 1.
DR Pfam; PF17177; PPR_long; 1.
DR PROSITE; PS51375; PPR; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 225..323
FT /note="Pentacotripeptide-repeat region of PRORP"
FT /evidence="ECO:0000259|Pfam:PF17177"
FT REPEAT 240..274
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 532..567
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 823..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1010
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 115951 MW; C3100E98242CF24D CRC64;
MLTPTRRLPK ALSPYAQALR HVALRGATAF GPGAKEMELD MLRKGTLPAD YRPPVQGRWD
DTIERWAYAW QFPAEEEQDD ITKSVERNAS GMQALLEIGN KLLRSPPSPE PLSGKASKLY
PPVGDMSSGN TALLPPNPTY DVLEQDVSEL MAEDAVVVAS QPRLRAEELS AKYNVPMAYI
DDSSEASNAS KSLALVMEDV GLEFTEDGLT VVISALSRQG YGTIGRAIFD FASTMGLGPS
AEMYKALMKY ASRRGDVNES MALIEEMKGN GITPRIGNWH ELMYTFYKAK DYPAVSQIVD
NMKMYANIEP NEVTFVLQLK ALAKDNSQLN SLPEAIQLFD QMENVYGFIA SRPHYDAMMF
HLSQSPRPEM RLRCEELAHK MELMGIVWNA NTYLNLIRSA QVVGDVAAVE KYLSRMREEG
IPASIGHLTW AVQAHVQSMI RIDYDALKEK DESPLPTWLE HLETCFGIYE LVVRRGWVMQ
LPFVNALLRL TCQATILSME RTPDEAETIG RFEEQANKIW NHTFDEWQLQ KDVYSYECYI
ALLAHQQRID EAEKLFQEMI LKKDLSPSRR TYHCMIFMHL SSGEEGGTAR ALRYLEAMER
AGIQVRPSLL KKIVRVNNAA GYKRDMKRRA RRIMQAREEY LARKAEGVSF GEGGKEGASN
QRADVDAEGN SILEPLAVSP TSTLAWWEKW KRETVSKHEL FTEEGADGTP KGETFEEKNE
ALRMMGITSS FQTKDLVPQP DRQKLLPLIR REEGEIAGSL WAMDGGELSY PKDGGGPQGW
GVRLWRERQL VKREYQKVLD GYRPVPQLST LGNSVRTAGD QLDIERSGAQ TPGELSDYRN
FPDNRFDGGQ LKPESEAAPA VPFSAELVWQ GEANDKLSPY KSDEEIALEN DNTFFSSLSK
ETEGKLSIAV KAMQNKEENS VDVRGKGVTR RSKFDYLEKW RDMYRHGTLE VPEGPTLNFG
RTPDDHKETM AALVRGWYQR NRKEPASEEE LKRWRVDEQR SSETSASRAA LKKRKQVRSR
HRNK
//