ID Q4H337_CIOIN Unreviewed; 415 AA.
AC Q4H337; A0A1W2VP30;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Transforming growth factor beta superfamily signaling ligand {ECO:0000313|EMBL:BAE06590.1};
GN Name=Ci-nodal {ECO:0000313|EMBL:BAE06590.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:BAE06590.1};
RN [1] {ECO:0000313|EMBL:BAE06590.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12736827; DOI=10.1007/s00427-003-0330-z;
RA Satou Y., Satoh N.;
RT "Genomewide surveys of developmentally relevant genes in Ciona
RT intestinalis.";
RL Dev. Genes Evol. 213:211-212(2003).
RN [2] {ECO:0000313|EMBL:BAE06590.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15269171; DOI=10.1242/dev.01270;
RA Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.;
RT "Gene expression profiles of transcription factors and signaling molecules
RT in the ascidian embryo: towards a comprehensive understanding of gene
RT networks.";
RL Development 131:4047-4058(2004).
RN [3] {ECO:0000313|EMBL:BAE06590.1}
RP NUCLEOTIDE SEQUENCE.
RA Satou Y.;
RT "Expressed genes in Ciona intestinalis.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AB210585; BAE06590.1; -; mRNA.
DR RefSeq; NP_001072000.1; NM_001078532.1.
DR AlphaFoldDB; Q4H337; -.
DR GeneID; 778979; -.
DR KEGG; cin:778979; -.
DR CTD; 4838; -.
DR OrthoDB; 5393576at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF296; TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..415
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010392912"
FT DOMAIN 293..415
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 192..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 47953 MW; 1782DDFA395F1E83 CRC64;
MISMFNIAAF VFTMTSIFVN GESVTSSNPT NAEALLRHMQ QRSNAVRSKY MMELYRAKNT
GMPTNNALKR SDIVRSFRSI ESYKVGSRLV VVFDLSSVPR ERIRGSELQV DRSLSDVTMI
ELWEGVNAES RRKIGTMRYI RTNKSFDTTS QIRRWHRGDS PVTPFHASGA ILPLTPLLVV
YSNNHHYDLI EASESRMNRQ RRSSRGRHSN RYRKRRYRVN KNKTRKSTLR HNDVEITSHA
QQKSQRISND FELSTSSADD VTIQSGNEYD VTDEWRKQQS DDVKVVKAKH PVSPQRKHPF
IISTPAPRVG ATHCRKVSFE IDFEKIGWGS WIVYPKKYNA YRCEGQCRTP MRSDSKPTNH
AYMQSIIATK RPDLHIPQPC CVPTKLKPLS ILYYEDGEVK QRDHEDMVVD ECGCR
//
