ID Q4H3K8_CIOIN Unreviewed; 761 AA.
AC Q4H3K8; A0A1W2VNK8;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 03-MAY-2023, entry version 106.
DE SubName: Full=Transcription factor protein {ECO:0000313|EMBL:BAE06419.1};
GN Name=Ci-ets/pointed2 {ECO:0000313|EMBL:BAE06419.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:BAE06419.1};
RN [1] {ECO:0000313|EMBL:BAE06419.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12736827; DOI=10.1007/s00427-003-0330-z;
RA Satou Y., Satoh N.;
RT "Genomewide surveys of developmentally relevant genes in Ciona
RT intestinalis.";
RL Dev. Genes Evol. 213:211-212(2003).
RN [2] {ECO:0000313|EMBL:BAE06419.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15269171; DOI=10.1242/dev.01270;
RA Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.;
RT "Gene expression profiles of transcription factors and signaling molecules
RT in the ascidian embryo: towards a comprehensive understanding of gene
RT networks.";
RL Development 131:4047-4058(2004).
RN [3] {ECO:0000313|EMBL:BAE06419.1}
RP NUCLEOTIDE SEQUENCE.
RA Satou Y.;
RT "Expressed genes in Ciona intestinalis.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; AB210414; BAE06419.1; -; mRNA.
DR RefSeq; NP_001071702.1; NM_001078234.1.
DR AlphaFoldDB; Q4H3K8; -.
DR GeneID; 778601; -.
DR KEGG; cin:778601; -.
DR CTD; 778601; -.
DR OrthoDB; 3915960at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08533; SAM_PNT-ETS-1_2; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF289; ETS-LIKE PROTEIN POINTED; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019}.
FT DOMAIN 233..318
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 652..732
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 123..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..366
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..521
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 86572 MW; 2057D3C7A336BCE6 CRC64;
MVDQHVVPSS FDINIPSINI KPDDDFFDND LDFDVKLSNE DFSSPEDFVS TPVLPDDFLP
DLNHCSIKQS SFDKQIAYEN LSAHDASHIQ CNESTEYSSS YNGKHEVCTP VKNYPGKGKD
ICNITPNVTP RSAQKSMPGT PQSRSEQTMS GRKRRPQLTL QMPSFDDAAQ EVPTGQEYGS
ATPSCGLESG AGTPLEELTG LPEKLAPEDV PKTPLFPLIT PGTGAKMNDA ITQSFSSFRN
IMEANSMSKD PKLWSAPQVK TWARWIAQEF SIPSLDESNF CISGSMMCSL RKESFLHLCP
PFVGEILWEH LDRLQSECGN DTRIPECSNL NQNNDKISSS TTPQNPPSCT TNPPYPTRPA
PPYTKNPSFN QPIQNHFSLD QPPQFKEERY RPRHLDTPSH FNPTDAPPVD MSCVKREQLP
HYPSHAFPVN TNRRNFSFEH SMNIKPEPMS HINAFDMHRQ MSHPHKPNQR FGMHMENRRS
SEPILTPLKP FYRHRPLSQQ MSHPFPTPTT PNAPELPGHP MHLPPHEMGG QQNLQDLYYI
NIASLRHHQQ IETMKRHEMA KGKIQQTITN RSFGDQQVNQ HHMLSRSDSV GWNGNKGNIN
GLLTPEPEDF EGGFMQHSRM NSCMTQNTTA EFPSNPVIPG AFLTGYNGSG PIQLWQFLIE
LLTDRSCQHF VTWTGDGWEF KMIDPDEVAR RWGRRKNKPK MNYEKLSRGL RYYYDKNIIQ
KTAGRRYVYR FVCDLQSLLG YSPTELHSML DVKPEDRLSD D
//
