ID Q4JFV4_RAT Unreviewed; 365 AA.
AC Q4JFV4; A0A0G2JZN4;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Nucleic acid binding protein {ECO:0000313|EMBL:AAY88225.1};
GN Name=AABR07043347.1 {ECO:0000313|Ensembl:ENSRNOP00000071117.2,
GN ECO:0000313|RGD:15006392};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAY88225.1};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000071117.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071117.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|EMBL:AAY88225.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18073200; DOI=10.1093/nar/gkm1045;
RA Kirilyuk A., Tolstonog G.V., Damert A., Held U., Hahn S., Lower R.,
RA Buschmann C., Horn A.V., Traub P., Schumann G.G.;
RT "Functional endogenous LINE-1 retrotransposons are expressed and mobilized
RT in rat chloroleukemia cells.";
RL Nucleic Acids Res. 36:648-665(2008).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000071117.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071117.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQ100481; AAY88225.1; -; mRNA.
DR STRING; 10116.ENSRNOP00000071117; -.
DR Ensembl; ENSRNOT00000074702.3; ENSRNOP00000071117.2; ENSRNOG00000051410.2.
DR AGR; RGD:15006392; -.
DR RGD; 15006392; AABR07043347.1.
DR VEuPathDB; HostDB:ENSRNOG00000051410; -.
DR GeneTree; ENSGT01050000244818; -.
DR OMA; QYPTHER; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000051410; Expressed in jejunum and 9 other cell types or tissues.
DR Gene3D; 3.30.250.20; L1 transposable element, C-terminal domain; 1.
DR Gene3D; 3.30.70.1820; L1 transposable element, RRM domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR InterPro; IPR042566; L1_C.
DR InterPro; IPR035300; L1_dsRBD.
DR InterPro; IPR043636; L1_RRM_dom.
DR InterPro; IPR004244; Transposase_22.
DR PANTHER; PTHR11505; L1 TRANSPOSABLE ELEMENT-RELATED; 1.
DR PANTHER; PTHR11505:SF216; LINE-1 RETROTRANSPOSABLE ELEMENT ORF1 PROTEIN; 1.
DR Pfam; PF17490; Tnp_22_dsRBD; 1.
DR Pfam; PF02994; Transposase_22; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 185..282
FT /note="L1 transposable element RRM"
FT /evidence="ECO:0000259|Pfam:PF02994"
FT DOMAIN 286..347
FT /note="L1 transposable element dsRBD-like"
FT /evidence="ECO:0000259|Pfam:PF17490"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..161
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 365 AA; 42765 MW; D722FF78FCF49279 CRC64;
MSEIAEQSNT RDNLMVRGKR RKPSNRNQDY MAPSEPNSPI KTKKEYPNTP EKQDLVSKSF
LIMMLEDFKK DIKNSHREQV EAYREESQKS LKECQENTIK QLKELKMEIE AIKKEHMETT
LDIENQKKRQ GAVDTSFTNR IQEMEERISG AEDSIEIIDS TVKDNVKQKK LLVQNIQEIQ
HSMRRSNLRI IGIEENEDSQ LKGPVNIFNK IIEENFPNLK KEIPIDIQED YRTPNRLDQK
RNTSRHIIVK TPNAQNKERI LKAVREKGQV TYKGRPIRIT PDFSPETMKA RRSWTDVIQT
LREHKCQPRL LCPAKLSINI DGETKIFHDK TKFIQYLSTN PALQRIINGK AQHKEASYTL
EEARN
//
