ID COX2_TETNG Reviewed; 230 AA.
AC Q4JQI4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 01-MAY-2013, entry version 54.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
GN Name=mt-co2; Synonyms=coii, coxii, mtco2;
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes;
OC Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17076253; DOI=10.1080/10425170600700378;
RA Yue G.H., Lo L.C., Zhu Z.Y., Lin G., Feng F.;
RT "The complete nucleotide sequence of the mitochondrial genome of
RT Tetraodon nigroviridis.";
RL DNA Seq. 17:115-121(2006).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. Subunit 2
CC transfers the electrons from cytochrome c via its binuclear copper
CC A center to the bimetallic center of the catalytic subunit 1.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- COFACTOR: Copper A.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR EMBL; DQ019313; AAY26161.1; -; Genomic_DNA.
DR RefSeq; YP_254664.1; NC_007176.1.
DR ProteinModelPortal; Q4JQI4; -.
DR SMR; Q4JQI4; 1-227.
DR Ensembl; ENSTNIT00000004109; ENSTNIP00000002153; ENSTNIG00000000112.
DR GeneID; 3453251; -.
DR CTD; 4513; -.
DR eggNOG; COG1622; -.
DR GeneTree; ENSGT00390000017410; -.
DR HOVERGEN; HBG012727; -.
DR OrthoDB; EOG4BZN3N; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR014222; Cyt_c_oxidase_su2.
DR InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR Pfam; PF00116; COX2; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR SUPFAM; SSF49503; Cupredoxin; 1.
DR SUPFAM; SSF81464; Cyt_c_oxidase_II-like_TM; 1.
DR TIGRFAMs; TIGR02866; CoxB; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 3: Inferred from homology;
KW Complete proteome; Copper; Electron transport; Membrane;
KW Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Oxidoreductase; Reference proteome; Respiratory chain; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 230 Cytochrome c oxidase subunit 2.
FT /FTId=PRO_0000183702.
FT TOPO_DOM 1 26 Mitochondrial intermembrane (Potential).
FT TRANSMEM 27 48 Helical; (Probable).
FT TOPO_DOM 49 62 Mitochondrial matrix (Potential).
FT TRANSMEM 63 82 Helical; (Probable).
FT TOPO_DOM 83 230 Mitochondrial intermembrane (Potential).
FT METAL 161 161 Copper A (Probable).
FT METAL 196 196 Copper A (Probable).
FT METAL 200 200 Copper A (Probable).
FT METAL 204 204 Copper A (Probable).
SQ SEQUENCE 230 AA; 26051 MW; 774E06637300CC15 CRC64;
MAHPSQLGFQ DAASPVMEEL LHFHDHALMI VFLISTLVLY IIAATASTKL TDKYILDSQE
IEVIWTIMPA VILILIALPS LRILYLMDEI NDPHLTVKTM GHQWYWSYEY TDYDDLSFDS
YMIPTQDLTP GQFRLLETDH RMVIPVDSPI RVLVSAEDVL HSWAVPSLGI KMDAVPGRLN
QTAFIVSRPG VFYGQCSEIC GANHSFMPIV VEAVPLEHFE NWSSLMLEDA
//
