ID Q4K2Z0_STREE Unreviewed; 283 AA.
AC Q4K2Z0;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 13-SEP-2023, entry version 70.
DE RecName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000256|RuleBase:RU364082};
DE EC=1.1.1.133 {ECO:0000256|RuleBase:RU364082};
GN Name=rmlD {ECO:0000313|EMBL:CAI32828.1};
GN ORFNames=SPC06A_0018 {ECO:0000313|EMBL:CAI32828.1};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:CAI32828.1};
RN [1] {ECO:0000313|EMBL:CAI32828.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=34351 {ECO:0000313|EMBL:CAI32828.1};
RX PubMed=16532061; DOI=10.1371/journal.pgen.0020031;
RA Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA Spratt B.G.;
RT "Genetic analysis of the capsular biosynthetic locus from all 90
RT pneumococcal serotypes.";
RL PLoS Genet. 2:262-268(2006).
RN [2] {ECO:0000313|EMBL:AEO88365.1}
RP NUCLEOTIDE SEQUENCE.
RA Elberse K.E., Witteveen S., van der Heide H., van de Pol I., Schot C.,
RA van der Ende A., Berbers G., Schouls L.;
RT "Sequence Diversity within the Capsular Genes of Streptococcus pneumoniae
RT Serogroup 6 and 19.";
RL PLoS ONE 6:e25018-e25018(2011).
CC -!- FUNCTION: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to
CC yield dTDP-L-rhamnose. {ECO:0000256|RuleBase:RU364082}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-
CC rhamnose + H(+) + NADPH; Xref=Rhea:RHEA:21796, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57510, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:62830; EC=1.1.1.133;
CC Evidence={ECO:0000256|RuleBase:RU364082};
CC -!- PATHWAY: Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.
CC {ECO:0000256|RuleBase:RU364082}.
CC -!- SIMILARITY: Belongs to the dTDP-4-dehydrorhamnose reductase family.
CC {ECO:0000256|ARBA:ARBA00010944, ECO:0000256|RuleBase:RU364082}.
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DR EMBL; JF911492; AEO88365.1; -; Genomic_DNA.
DR EMBL; JF911494; AEO88393.1; -; Genomic_DNA.
DR EMBL; CR931638; CAI32828.1; -; Genomic_DNA.
DR RefSeq; WP_000600911.1; NZ_JACVIR010000017.1.
DR AlphaFoldDB; Q4K2Z0; -.
DR UniPathway; UPA00124; -.
DR GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR NCBIfam; TIGR01214; rmlD; 1.
DR PANTHER; PTHR10491; DTDP-4-DEHYDRORHAMNOSE REDUCTASE; 1.
DR PANTHER; PTHR10491:SF4; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|RuleBase:RU364082};
KW Oxidoreductase {ECO:0000256|RuleBase:RU364082,
KW ECO:0000313|EMBL:CAI32828.1}.
FT DOMAIN 2..280
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 283 AA; 32388 MW; 7FB8B0E8C25218F8 CRC64;
MILITGANGQ LGTELRYLLD ERNEEYVAVD VAEMDITNEE MVEKVFEEVK PTLVYHCAAY
TAVDAAEDEG KELDFAINVT GTKNVAKASE KHGATLVYIS TDYVFDGKKP VGQEWEVDDR
PDPQTEYGRT KRMGEELVEK HVSNFYIIRT AWVFGNYGKN FVFTMQNLAK THKTLTVVND
QYGRPTWTRT LAEFMTYLAE NRKEFGYYHL SNDATEDTTW YDFAVEILKD TDVEVKPVDS
SQFPVKAKRP LNSTMSLAKA KATGFVIPTW QDALQEFYKQ EVR
//
