ID CHPT1_XENLA Reviewed; 402 AA.
AC Q4KLV1;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-OCT-2012, entry version 43.
DE RecName: Full=Cholinephosphotransferase 1;
DE EC=2.7.8.2;
DE AltName: Full=Diacylglycerol cholinephosphotransferase 1;
GN Name=chpt1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes phosphatidylcholine biosynthesis from CDP-
CC choline. It thereby plays a central role in the formation and
CC maintenance of vesicular membranes (By similarity).
CC -!- CATALYTIC ACTIVITY: CDP-choline + 1,2-diacylglycerol = CMP + a
CC phosphatidylcholine.
CC -!- COFACTOR: Magnesium or manganese (By similarity).
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine
CC biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass
CC membrane protein (By similarity).
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase
CC class-I family.
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DR EMBL; BC098988; AAH98988.1; -; mRNA.
DR RefSeq; NP_001089575.1; NM_001096106.1.
DR UniGene; Xl.51860; -.
DR GeneID; 734631; -.
DR KEGG; xla:734631; -.
DR CTD; 56994; -.
DR Xenbase; XB-GENE-6489129; chpt1.
DR HOVERGEN; HBG107647; -.
DR KO; K00994; -.
DR UniPathway; UPA00753; UER00740.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0004142; F:diacylglycerol cholinephosphotransferase activity; IEA:EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006657; P:CDP-choline pathway; IEA:GOC.
DR InterPro; IPR000462; CDP-OH_P_trans.
DR InterPro; IPR014472; CHOPT.
DR Pfam; PF01066; CDP-OH_P_transf; 1.
DR PIRSF; PIRSF015665; CHOPT; 1.
DR PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Magnesium;
KW Manganese; Membrane; Metal-binding; Phospholipid biosynthesis;
KW Phospholipid metabolism; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 402 Cholinephosphotransferase 1.
FT /FTId=PRO_0000289257.
FT TRANSMEM 66 86 Helical; (Potential).
FT TRANSMEM 93 113 Helical; (Potential).
FT TRANSMEM 131 151 Helical; (Potential).
FT TRANSMEM 153 173 Helical; (Potential).
FT TRANSMEM 186 206 Helical; (Potential).
FT TRANSMEM 226 248 Helical; (Potential).
FT TRANSMEM 261 281 Helical; (Potential).
FT TRANSMEM 295 315 Helical; (Potential).
FT TRANSMEM 343 363 Helical; (Potential).
SQ SEQUENCE 402 AA; 44513 MW; 787A412C501ABFFA CRC64;
MGLAEGLAAR MAPHLYIQEP LSAQQLKKLE EHKYSASGRS LVEPPMQVYW NWLVEKVPLW
LAPNTITMVG LLLNVLSTLI LVCYCPTATE GAPFWTYLLC AIGLFVYQSL DAIDGKQARR
TNSSSPLGEM FDHGCDSISI VFVNLGTIAA VRLGTLPGWM FYCCFVGMFM FYCAQWQTYV
CGTLKFGIID VTELQISVTV MFLMTAVCGP ELWDYEIPFT GLPMKTIPLL GIIGGTVYSC
SNYFRVILSG GVGKNGSTVA GTSVLSPGLH IGLVLLLALM IYKKSTTNLF LQNPCLYTLA
FGFVSAKITI KLVIAHMTKS EISLQDTAFI GPGLLFFNQY FNSFIDEYIV LWIAMVISFA
DLLRYCISVC LQIATHLRIS VFRISSNQAA EQVQTQKQKL TD
//
