ID Q4LE69_HUMAN Unreviewed; 2121 AA.
AC Q4LE69;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 28-JUN-2023, entry version 116.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
DE Flags: Fragment;
GN Name=PIK4CA variant protein {ECO:0000313|EMBL:BAE06084.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE06084.1};
RN [1] {ECO:0000313|EMBL:BAE06084.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAE06084.1};
RA Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R.,
RA Okazaki N., Koga H., Nagase T., Ohara O.;
RT "Preparation of a set of expression-ready clones of mammalian long cDNAs
RT encoding large proteins by the ORF trap cloning method.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB210002; BAE06084.1; -; mRNA.
DR RefSeq; NP_477352.3; NM_058004.3.
DR IntAct; Q4LE69; 1.
DR PeptideAtlas; Q4LE69; -.
DR DNASU; 5297; -.
DR GeneID; 5297; -.
DR KEGG; hsa:5297; -.
DR CTD; 5297; -.
DR PharmGKB; PA162399305; -.
DR OrthoDB; 147843at2759; -.
DR BioGRID-ORCS; 5297; 464 hits in 1177 CRISPR screens.
DR ChiTaRS; PI4KA; human.
DR GenomeRNAi; 5297; -.
DR Genevisible; Q4LE69; HS.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 2: Evidence at transcript level;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1549..1737
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1827..2105
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAE06084.1"
SQ SEQUENCE 2121 AA; 238697 MW; 5B3CEC2D4645DFB6 CRC64;
GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY FNTVLSLARS
LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL GIFLIESDLQ HKDCVVPYLL
RLLKGLPKVY WVEESTARKG RGALPVAESF SFCLVTLLSD VAYRDPSLRD EILEVLLQVL
HVLLGMCQAL EIQDKEYLCK YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE
ELEGVRRRSF NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF
HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE LLNLVKKIVE
EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML RDTLYYMKDL PTSFVKEIHD
FVLEQFNTSQ GELQKILHDA DRIHNELSPL KLRCQANAAC VDLMVWAVKD EQGAENLCIK
LSEKLQSKTS SKVIIAHLPL LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL
YKYHSQYHTV AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL
TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP KVMEPILQIL
QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ ISVKASSVVY SATKDYKDHG
YRHCSLAVIN ALANIAANIQ DEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS
SSAGNLGVLI PVIAVLTRRL PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE
GVCEIATKSP LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL
INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG MMQCVIAVAD
KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR IRRVADKYLS GLVDKFPHLL
WSGTVLKTML DILQTLSLSL SADIHKDQPY YDIPDAPYRI TVPDTYEARE SIVKDFAARC
GMILQEAMKW APTVTKSHLQ EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG
ATQLSERPAC VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL
DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL ACWEWLLAGK
DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE ASQPKPCPPE VTPHYIWIDF
LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH
ADVVPNATIR NVLREKIYST AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL
TASQLVPPDN QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL
HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK YISLSEKQWK
DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG AVSDVPEAIK FLVTWHTIDA
DAPELSHVLC WAPTDPPTGL SYFSSMYPPH PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL
RYDKMGYVRE YILWAASKSQ LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG
SLSGPAKDFY QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE
AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE CSTQEADGQK
ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV FPYRVVATAP GCGVIECIPD
CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA FQQARYNFIR SMAAYSLLLF LLQIKDRHNG
NIMLDKKGHI IHIDFGFMFE SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV
RGYLAVRPYM DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC
FLSNRSRTYD MIQYYQNDIP Y
//