GenomeNet

Database: UniProt
Entry: Q4LE69_HUMAN
LinkDB: Q4LE69_HUMAN
Original site: Q4LE69_HUMAN 
ID   Q4LE69_HUMAN            Unreviewed;      2121 AA.
AC   Q4LE69;
DT   02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   02-AUG-2005, sequence version 1.
DT   28-JUN-2023, entry version 116.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
DE   Flags: Fragment;
GN   Name=PIK4CA variant protein {ECO:0000313|EMBL:BAE06084.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE06084.1};
RN   [1] {ECO:0000313|EMBL:BAE06084.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAE06084.1};
RA   Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R.,
RA   Okazaki N., Koga H., Nagase T., Ohara O.;
RT   "Preparation of a set of expression-ready clones of mammalian long cDNAs
RT   encoding large proteins by the ORF trap cloning method.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB210002; BAE06084.1; -; mRNA.
DR   RefSeq; NP_477352.3; NM_058004.3.
DR   IntAct; Q4LE69; 1.
DR   PeptideAtlas; Q4LE69; -.
DR   DNASU; 5297; -.
DR   GeneID; 5297; -.
DR   KEGG; hsa:5297; -.
DR   CTD; 5297; -.
DR   PharmGKB; PA162399305; -.
DR   OrthoDB; 147843at2759; -.
DR   BioGRID-ORCS; 5297; 464 hits in 1177 CRISPR screens.
DR   ChiTaRS; PI4KA; human.
DR   GenomeRNAi; 5297; -.
DR   Genevisible; Q4LE69; HS.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00871; PI4Ka; 1.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   2: Evidence at transcript level;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1549..1737
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1827..2105
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAE06084.1"
SQ   SEQUENCE   2121 AA;  238697 MW;  5B3CEC2D4645DFB6 CRC64;
     GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY FNTVLSLARS
     LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL GIFLIESDLQ HKDCVVPYLL
     RLLKGLPKVY WVEESTARKG RGALPVAESF SFCLVTLLSD VAYRDPSLRD EILEVLLQVL
     HVLLGMCQAL EIQDKEYLCK YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE
     ELEGVRRRSF NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF
     HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE LLNLVKKIVE
     EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML RDTLYYMKDL PTSFVKEIHD
     FVLEQFNTSQ GELQKILHDA DRIHNELSPL KLRCQANAAC VDLMVWAVKD EQGAENLCIK
     LSEKLQSKTS SKVIIAHLPL LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL
     YKYHSQYHTV AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL
     TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP KVMEPILQIL
     QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ ISVKASSVVY SATKDYKDHG
     YRHCSLAVIN ALANIAANIQ DEHLVDELLM NLLELFVQLG LEGKRASERA SEKGPALKAS
     SSAGNLGVLI PVIAVLTRRL PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE
     GVCEIATKSP LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL
     INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG MMQCVIAVAD
     KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR IRRVADKYLS GLVDKFPHLL
     WSGTVLKTML DILQTLSLSL SADIHKDQPY YDIPDAPYRI TVPDTYEARE SIVKDFAARC
     GMILQEAMKW APTVTKSHLQ EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG
     ATQLSERPAC VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL
     DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL ACWEWLLAGK
     DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE ASQPKPCPPE VTPHYIWIDF
     LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH
     ADVVPNATIR NVLREKIYST AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL
     TASQLVPPDN QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL
     HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK YISLSEKQWK
     DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG AVSDVPEAIK FLVTWHTIDA
     DAPELSHVLC WAPTDPPTGL SYFSSMYPPH PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL
     RYDKMGYVRE YILWAASKSQ LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG
     SLSGPAKDFY QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE
     AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE CSTQEADGQK
     ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV FPYRVVATAP GCGVIECIPD
     CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA FQQARYNFIR SMAAYSLLLF LLQIKDRHNG
     NIMLDKKGHI IHIDFGFMFE SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV
     RGYLAVRPYM DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC
     FLSNRSRTYD MIQYYQNDIP Y
//
DBGET integrated database retrieval system