ID Q4LEN2_LACLC Unreviewed; 119 AA.
AC Q4LEN2;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Cadmium resistance regulator CadC {ECO:0000313|EMBL:AFM72773.1};
DE SubName: Full=Cadmium resistance regulatory protein {ECO:0000313|EMBL:BAE06241.1};
DE SubName: Full=Metalloregulator ArsR/SmtB family transcription factor {ECO:0000313|EMBL:MRM79772.1};
GN Name=cadC {ECO:0000313|EMBL:BAE06241.1};
GN ORFNames=GJI91_13125 {ECO:0000313|EMBL:MRM79772.1}, pAF14_p10
GN {ECO:0000313|EMBL:AFM72773.1};
OS Lactococcus lactis subsp. cremoris (Streptococcus cremoris).
OG Plasmid pAF14 {ECO:0000313|EMBL:AFM72773.1}, and
OG Plasmid pAG6 {ECO:0000313|EMBL:BAE06241.1}.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1359 {ECO:0000313|EMBL:BAE06241.1};
RN [1] {ECO:0000313|EMBL:BAE06241.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=712 {ECO:0000313|EMBL:BAE06241.1};
RC PLASMID=pAG6 {ECO:0000313|EMBL:BAE06241.1};
RA Kobayashi M., Nomura M., Kimoto H., Suzuki C.;
RT "The entire nucreotide sequence of the cryptic plasmid pAG6 from
RT Lactococcus lactis ssp. cremoris 712.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFM72773.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DPC3758 {ECO:0000313|EMBL:AFM72773.1};
RC PLASMID=pAF14 {ECO:0000313|EMBL:AFM72773.1};
RX PubMed=22720917;
RA Fallico V., Ross R.P., Fitzgerald G.F., McAuliffe O.;
RT "Novel conjugative plasmids from the natural isolate Lactococcus lactis
RT subspecies cremoris DPC3758: A repository of genes for the potential
RT improvement of dairy starters.";
RL J. Dairy Sci. 95:3593-3608(2012).
RN [3] {ECO:0000313|EMBL:MRM79772.1, ECO:0000313|Proteomes:UP000430279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMQ450 {ECO:0000313|EMBL:MRM79772.1,
RC ECO:0000313|Proteomes:UP000430279};
RA Marcelli B., De Jong A.;
RT "Lactococcus lactis genomes.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JQ821356; AFM72773.1; -; Genomic_DNA.
DR EMBL; AB198069; BAE06241.1; -; Genomic_DNA.
DR EMBL; WJVA01000089; MRM79772.1; -; Genomic_DNA.
DR RefSeq; WP_003726380.1; NZ_WJVA01000089.1.
DR RefSeq; YP_006964751.1; NC_019350.1.
DR RefSeq; YP_263295.1; NC_007191.1.
DR SMR; Q4LEN2; -.
DR GeneID; 84701732; -.
DR PATRIC; fig|1359.24.peg.2925; -.
DR Proteomes; UP000430279; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR018334; ArsR_HTH.
DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; NF033788; HTH_metalloreg; 1.
DR PANTHER; PTHR43132; ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED; 1.
DR PANTHER; PTHR43132:SF6; TRANSCRIPTIONAL REPRESSOR SMTB HOMOLOG; 1.
DR Pfam; PF01022; HTH_5; 1.
DR PRINTS; PR00778; HTHARSR.
DR SMART; SM00418; HTH_ARSR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00846; HTH_ARSR_1; 1.
DR PROSITE; PS50987; HTH_ARSR_2; 1.
PE 4: Predicted;
KW Cadmium resistance {ECO:0000256|ARBA:ARBA00043263};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Plasmid {ECO:0000313|EMBL:BAE06241.1}.
FT DOMAIN 23..118
FT /note="HTH arsR-type"
FT /evidence="ECO:0000259|PROSITE:PS50987"
SQ SEQUENCE 119 AA; 13382 MW; B34C01C21DC2C944 CRC64;
MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL VHEDELCVCD
IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN IKILNLMELG VNFKEEVLA
//
