ID Q4MZ82_THEPA Unreviewed; 476 AA.
AC Q4MZ82;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
GN OrderedLocusNames=TP03_0216 {ECO:0000313|EMBL:EAN30951.1};
OS Theileria parva (East coast fever infection agent).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN30951.1, ECO:0000313|Proteomes:UP000001949};
RN [1] {ECO:0000313|EMBL:EAN30951.1, ECO:0000313|Proteomes:UP000001949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Muguga {ECO:0000313|EMBL:EAN30951.1,
RC ECO:0000313|Proteomes:UP000001949};
RX PubMed=15994558; DOI=10.1126/science.1110439;
RA Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT lymphocytes.";
RL Science 309:134-137(2005).
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC subfamily. {ECO:0000256|ARBA:ARBA00024355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN30951.1}.
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DR EMBL; AAGK01000005; EAN30951.1; -; Genomic_DNA.
DR RefSeq; XP_763234.1; XM_758141.1.
DR AlphaFoldDB; Q4MZ82; -.
DR STRING; 5875.Q4MZ82; -.
DR EnsemblProtists; EAN30951; EAN30951; TP03_0216.
DR GeneID; 3500147; -.
DR KEGG; tpv:TP03_0216; -.
DR VEuPathDB; PiroplasmaDB:TpMuguga_03g00216; -.
DR eggNOG; KOG0344; Eukaryota.
DR InParanoid; Q4MZ82; -.
DR OMA; DRALMAC; -.
DR Proteomes; UP000001949; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00268; DEADc; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24031:SF594; ATP-DEPENDENT RNA HELICASE DDX52-RELATED; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|RuleBase:RU365068, ECO:0000313|EMBL:EAN30951.1};
KW Hydrolase {ECO:0000256|RuleBase:RU365068};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000001949};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 100..265
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 293..438
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 317..344
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 476 AA; 53919 MW; 20B22A81305070F6 CRC64;
MDKIFKKLVR GTNFKNGPSS GIFVFRDGDK ESDSGVFDED FSVVNSSGED FNDYSPLDTF
SALDSLTTDD KISERAKVIS KSINSKLNFD KTTPIQRYVI PIMMKGNDVV AVAPTGSGKT
LSYLTPILLK NLEDSLSVII IVPTVELVQQ VKSEFIYLTG GEIFSIKALE KNMTEFNFSI
AITTPLTLYT LLHNNALKTD LMRGLKCLVL DECDKLLEEG YGENIEYIMN LIKDFKGIQK
ASFSSTLQSE VLLLSKSHFN NPIHITIGKE NVCCCNVEQE LICVTNDKGK LLILKQLIND
GKLLPPILVF LQSINRVNDL YNELSQLNLN VQKFTKQLTL KQRQNIIQKF RIGQIWILLC
TDILCRGINF KGVHSIVNYD LPLTPQVYIN RVGRAGRGTK RGKSVTFFTI NDFKILNHII
QIMKLSKSNI PQYLLSLKPI HIQQKRKNST NPNQQILNTQ PLTHEFKLWK VDPKNF
//