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Database: UniProt
Entry: Q4N1K4_THEPA
LinkDB: Q4N1K4_THEPA
Original site: Q4N1K4_THEPA 
ID   Q4N1K4_THEPA            Unreviewed;       936 AA.
AC   Q4N1K4;
DT   02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   02-AUG-2005, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   OrderedLocusNames=TP04_0731 {ECO:0000313|EMBL:EAN32084.1};
OS   Theileria parva (East coast fever infection agent).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN32084.1, ECO:0000313|Proteomes:UP000001949};
RN   [1] {ECO:0000313|EMBL:EAN32084.1, ECO:0000313|Proteomes:UP000001949}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Muguga {ECO:0000313|EMBL:EAN32084.1,
RC   ECO:0000313|Proteomes:UP000001949};
RX   PubMed=15994558; DOI=10.1126/science.1110439;
RA   Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M.,
RA   Hall N., Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M.,
RA   Sato S., Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J.,
RA   Jiang L., Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D.,
RA   Crabtree J., Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C.,
RA   Suh B., Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M.,
RA   Allen J., Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R.,
RA   Fitzhugh H.A., Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT   "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT   lymphocytes.";
RL   Science 309:134-137(2005).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAN32084.1}.
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DR   EMBL; AAGK01000004; EAN32084.1; -; Genomic_DNA.
DR   RefSeq; XP_764367.1; XM_759274.1.
DR   STRING; 333668.XP_764367.1; -.
DR   EnsemblProtists; EAN32084; EAN32084; TP04_0731.
DR   GeneID; 3501298; -.
DR   KEGG; tpv:TP04_0731; -.
DR   EuPathDB; PiroplasmaDB:TP04_0731; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; Q4N1K4; -.
DR   KO; K02154; -.
DR   Proteomes; UP000001949; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001949};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Hydrolase {ECO:0000313|EMBL:EAN32084.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001949};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    467    492       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    513    530       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    601    624       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    636    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    696    718       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    864    887       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   936 AA;  108217 MW;  877BFC968D3C93FF CRC64;
     MGIFRSETMV HGTLVIPHER ARNCIDLLSR HTNIQYIDMN ERRMDRPYKK YVQRIDHMER
     MIRVLYEEIA KLPNSKIVRH NIDNFLEHDN MYRLDQVEES LVKLYDQFQM FKENDSLLRR
     ERDEALSEYY VLLVASKQLN LLTPEKSYSD IPNTISLPVT NLDESSDSRE HLLNDNTQSD
     TEMINLSPYD STARVTSSIS FTNISGLISS QEKEAFSRAI FRAMRGNVFT LLHDTNDLRS
     MVLSKGLVDQ EELDTDNDKT VFVIYCQSSN NDATYNKIKK LCTGFQAKLF NWCKTQSELA
     PRLKTLEDVI KDKKRALEAY KDYFRGEIAC LLEVIRPGGN SVIEEWFLFC KKEKYLYYIL
     NHFEGSDITL RADCWFPADE EEKIREHLLA EKASGSVSAL LLVDIQAPFV SVHPSHPGSH
     ENLSHIPPTY NKTNMISKSF QNVVDTYGIP RYKEVNPAPF TVMTFPFLFG LMFGDIAHGI
     CVILFALFLI LYYRKLKRKF TGDIANMILE GRYMILLMGI MATYTGFIYN DFLSIPNSFF
     GTGWISNGTP PEGGSESDGT YVETLVRSAK NFPVVFGLDP AWIGAVNEQS VLHSFKMKFS
     VIFGFFQMTL GILLKGFNAI YFSSAIDFFF EFMPQLAMMC SFVGYMNFLI FHKWLTPLDN
     GYAKPSIITT LIDMCLMKTL EQHEIMYEGQ QTVQRVLMSI LIVSVPLMLI PKPLILYFRL
     KKQGRTRANN NSTRDYEMVY CGPEEEDLEA IARESVPNYP HRRSSLDLGL DKFKKVDAKN
     KDNQFSVTIQ KDENEASPAE QPHSLKLSEL FIHQFIETIE FTLGTISNTA SYLRLWALSL
     SHQQLSLVLF KQLIFNCLDN STSLLVMIFG LFIRSIFFSI FTFFIMLCMD SLECYLHALR
     LQWVEFQNKF FKADGRFFRP FNIKLLLDDP TIMEPK
//
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