ID ERB1_USTMA Reviewed; 932 AA.
AC Q4P2E9; A0A0D1DSR7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 103.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=UMAG_05714;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
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DR EMBL; CM003155; KIS66931.1; -; Genomic_DNA.
DR RefSeq; XP_011391464.1; XM_011393162.1.
DR AlphaFoldDB; Q4P2E9; -.
DR SMR; Q4P2E9; -.
DR STRING; 237631.Q4P2E9; -.
DR EnsemblFungi; KIS66931; KIS66931; UMAG_05714.
DR GeneID; 23565526; -.
DR KEGG; uma:UMAG_05714; -.
DR VEuPathDB; FungiDB:UMAG_05714; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; Q4P2E9; -.
DR OMA; MRPAKGE; -.
DR OrthoDB; 5472008at2759; -.
DR Proteomes; UP000000561; Chromosome 16.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IEA:EnsemblFungi.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..932
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370442"
FT REPEAT 555..594
FT /note="WD 1"
FT REPEAT 604..644
FT /note="WD 2"
FT REPEAT 762..800
FT /note="WD 3"
FT REPEAT 803..842
FT /note="WD 4"
FT REPEAT 846..885
FT /note="WD 5"
FT REPEAT 901..932
FT /note="WD 6"
FT REGION 1..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..115
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..167
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 103046 MW; B9FEF03EF3673F02 CRC64;
MVRPSSSSSA SASAARSGAA KRKRNLPTAT NPTTRASVAA NVKGKGKTKA LELDLVVSDD
GEEDGELDLE SDSGDDDAND DDDNDNEQDD FPEIDLEDSD DDQDVEDEDE PGAQEEVDSD
NNKQASTQVH DIQVEEDDSS EEGYNSSDID NSDFDDDADE GDLAYDSADE DERASAFAAR
SDASQTSIDE ELSRMMSRYS SKPDEHSGSL SATNKLGIPR SQAAQAFDLR VRNPDGSAKG
VFKRSEITGE MKRVYPEIDA AYDSDSSTED PENRIGNVPL EWYDDLPHIG YDINGRKVMK
PATKDELDKF LDTVDGDGEA WFSARDKSTG KDVRLSDEEL AIIRKLQNAE IPDDAYDPYE
DYVDWFTGED KVMQTALSGR PEPKSRFVPS KWEHKKVMKI VRAIREGRIV PGAAANKDAK
PKFYNIWADA HENDTRSPWA VMAAPKLALP GHAESYNPPA EYLFNEQEQK EWQEAEAEDR
KQNFLPTKHD SLRRVGAYQN FVQERFERCL DLYLAPRMMR KKLDIHNPEN LLPKLPSPKE
LRPFPITTSV VYVHPDGGRV RCLSVDPTGN WLVTGGDDGR ARLWDVAIGR CTASWDVCEG
MPKAERSAVH SIAWCPTKNY SLFTAVVHGR VAVIAPPQTQ NYAKTSANAI SSKSASSSSG
ATATSTASFL YATSAAATSM PSKPDARSPV AWTRPSEAER RTGVAMHLNI TSPSAANLKT
VVWHNKGDYF ATVCPDSAAG SAGLLIHQLS KHRSQSPFRK ASKGSSIQKL VFHPTKPWIF
VATQRYIRIY DLMAQSLIKT LQSGFKWIST LDVHPSGDHL MVGSYDKKLA WFDLDLSARP
YKVLKYHARA IRSVHFSTSW NLVADASDDG TLQLFYAKVG ADYGENLTLV PLKVLRGHEV
KNGLGVLDVK WHPNQPWLFS AGADGNALLW TT
//
