ID Q4Q055_LEIMA Unreviewed; 731 AA.
AC Q4Q055;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE SubName: Full=Putative eukaryotic translation initiation factor 3 subunit 8 {ECO:0000313|EMBL:CAJ09680.1};
GN ORFNames=LMJF_36_6980 {ECO:0000313|EMBL:CAJ09680.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ09680.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ09680.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ09680.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796432; CAJ09680.1; -; Genomic_DNA.
DR RefSeq; XP_001687293.1; XM_001687241.1.
DR AlphaFoldDB; Q4Q055; -.
DR STRING; 5664.Q4Q055; -.
DR EnsemblProtists; CAJ09680; CAJ09680; LMJF_36_6980.
DR GeneID; 5656015; -.
DR KEGG; lma:LMJF_36_6980; -.
DR VEuPathDB; TriTrypDB:LmjF.36.6980; -.
DR VEuPathDB; TriTrypDB:LMJFC_360091100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_360085300; -.
DR VEuPathDB; TriTrypDB:LMJSD75_360085100; -.
DR eggNOG; KOG1076; Eukaryota.
DR HOGENOM; CLU_379239_0_0_1; -.
DR InParanoid; Q4Q055; -.
DR OMA; NAGNESW; -.
DR Proteomes; UP000000542; Chromosome 36.
DR GO; GO:0005737; C:cytoplasm; IPI:GeneDB.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IPI:GeneDB.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; ISM:GeneDB.
DR InterPro; IPR027516; EIF3C.
DR InterPro; IPR008905; EIF3C_N_dom.
DR PANTHER; PTHR13937; EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED; 1.
DR PANTHER; PTHR13937:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED; 1.
DR Pfam; PF05470; eIF-3c_N; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:CAJ09680.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 266..526
FT /note="Eukaryotic translation initiation factor 3 subunit C
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05470"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 82032 MW; FAAF1B71FC16AD55 CRC64;
MNFFAISSSD SDSESEKSLL REEVSEAQIN PFWFEWTDEE ELEERQEVIP KKEKAANSIQ
ALCDTFDYNA GNESWREALE AFKRMCDEVH TFVRKYKVAP QGLQNCLQDM PNLAEHLEGK
GREDFANRLE FKSLKELVAL VEETEKLYKK ELEELAKGPE NDDGAQDEDE DAGAELTEAE
YAQILEDISG SREVNLVGKV EKVIRACARK GYTNLEISAM GIAVSAVLRR DSRKLLVSSD
TWERAFKWGA KFFSRMIAAT NVRFVEDSSS VNARNIVVPG GIHGFLTYLH TELVNKSKFE
EVASQEYLKI ITFENELAVL ADRALGYYQA RKRIEPSKAC ISILFDILGQ RRQEAHQLFY
DSLSSTDSLT IISKSVFDTV RALHKLSLQL RPSVALSASG VCHVAYQYGL RGLYREGRDY
LLRTGVVNSI AVSDAPLAIL LNRAIAQLGL AAFIAGDIPT AHQLLRTIWG LRSNQVLIGQ
SPPPKSVLDD EHAEMEYRNL LLPPHMHMPV AQLELASVLS GLLMGVKMEA QNPYERNHME
RYVYNTVTRT PDLMGKPFSF KEQVAVAYEH LKAGNYIGAK EQVEAMTTFD TLPLGKETRK
RYLQRLKEVA LLVFCYTNRT NFSTMSVVNL AIKFDMEESD VRRAVNEILS ENTTLSAYWD
RDDAYLYLDR NNATRLQHLV KGTSESISNL AKHCESRLRA NGGRGRGRGG MAGGRGGAGV
RGAGGRGRGS R
//
