ID Q4Q1H4_LEIMA Unreviewed; 445 AA.
AC Q4Q1H4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=Putative acid phosphatase {ECO:0000313|EMBL:CAJ09205.1};
GN ORFNames=LMJF_36_2470 {ECO:0000313|EMBL:CAJ09205.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ09205.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ09205.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ09205.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR EMBL; FR796432; CAJ09205.1; -; Genomic_DNA.
DR RefSeq; XP_001686824.1; XM_001686772.1.
DR AlphaFoldDB; Q4Q1H4; -.
DR EnsemblProtists; CAJ09205; CAJ09205; LMJF_36_2470.
DR GeneID; 5655519; -.
DR KEGG; lma:LMJF_36_2470; -.
DR VEuPathDB; TriTrypDB:LmjF.36.2470; -.
DR VEuPathDB; TriTrypDB:LMJFC_360036400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_360032600; -.
DR VEuPathDB; TriTrypDB:LMJSD75_360032600; -.
DR eggNOG; ENOG502QWMV; Eukaryota.
DR HOGENOM; CLU_579372_0_0_1; -.
DR InParanoid; Q4Q1H4; -.
DR OMA; HGHRAPN; -.
DR Proteomes; UP000000542; Chromosome 36.
DR GO; GO:0020022; C:acidocalcisome; ISO:GeneDB.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR11567:SF137; PHOSPHATASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
SQ SEQUENCE 445 AA; 51159 MW; F319135FEEDCF6BF CRC64;
MNVARLVSAF GLHSGRRNKP STAPETSYPV HPPVNINWTQ QSLDSNITKA ERKEILKSKL
VLTKLVVLNR HGHRAPNAPF WKMCPNDINS KKRYDVSAED LTGLGMEEEY NFGQYVRNTY
HAFLGDKFNR MLHYFRAVGE PRILQSAMAM AQGIFPDGFG PGGYLPSRPQ FVPIFSDMDT
HEYLLDDVPC FRRAENDSHR WIDKRYQNFI DDPNTGRVLK MIKEVCGEYI GAAEGYAYIK
TVADGLTFNS DIGLKVAKGR LTPEMLFSIR NVSLQLLMQR LYGTDEQQTY MAVDLPRNIL
QTLNHTHVGD TPEQLNDFTD TRQESTFYFM HREALYAFAQ FFGFQYNVAG LPPGELPVAS
SIIMEKLVPH RDQYSHNASH IYVHITLWTP YNGIYTIPIS TCRIPELCEL KELQYIHDTR
VNRTGTWEQL CNYTPQEIDH TTDIR
//
