ID Q4Q2K4_LEIMA Unreviewed; 325 AA.
AC Q4Q2K4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=HECT domain-containing protein {ECO:0000259|Pfam:PF00632};
GN ORFNames=LMJF_34_3400 {ECO:0000313|EMBL:CAJ08061.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08061.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08061.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08061.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796430; CAJ08061.1; -; Genomic_DNA.
DR RefSeq; XP_001686444.1; XM_001686392.1.
DR AlphaFoldDB; Q4Q2K4; -.
DR EnsemblProtists; CAJ08061; CAJ08061; LMJF_34_3400.
DR GeneID; 5655117; -.
DR KEGG; lma:LMJF_34_3400; -.
DR VEuPathDB; TriTrypDB:LmjF.34.3400; -.
DR VEuPathDB; TriTrypDB:LMJFC_340044300; -.
DR VEuPathDB; TriTrypDB:LMJLV39_340039800; -.
DR VEuPathDB; TriTrypDB:LMJSD75_340040100; -.
DR eggNOG; ENOG502SMRE; Eukaryota.
DR HOGENOM; CLU_856499_0_0_1; -.
DR InParanoid; Q4Q2K4; -.
DR OMA; ASQEWNT; -.
DR Proteomes; UP000000542; Chromosome 34.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR Pfam; PF00632; HECT; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 38..109
FT /note="HECT"
FT /evidence="ECO:0000259|Pfam:PF00632"
SQ SEQUENCE 325 AA; 36717 MW; 317BE2EB76EDFF4E CRC64;
MNEAAPFCVA PQTWQGGLAR YPVSQSHVWN NNIILQPEDI DVEVFNAMSQ VESQYNKNEI
SVEDFEMLQL TFCLFTVNQS CYDLIPNGRE IRVTQANAFE FFQRVHAAYD NMKQRPALNQ
PTQSNHRPRL RTSGTRLRLT GQDTDSLEWI RWTAQNNPAA LAFHPDEPLR WAVVPRSRDF
MIRVQPEGEN TFVDPDHLTL FLDMLAVLLT EIERAISVFG YYPPNCVSAA PVECADEYSI
YTSHTTRATR LPFPSQRVNS RGFSALHKFP MPVTAAAAAA AAAATEQNRR TVRRASSADL
ENQRALCSPT HDTGGLLAPF QEWNV
//
