ID Q4Q2R4_LEIMA Unreviewed; 559 AA.
AC Q4Q2R4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 22-FEB-2023, entry version 69.
DE SubName: Full=Putative tuzin {ECO:0000313|EMBL:CAJ08001.1};
GN ORFNames=LMJF_34_2800 {ECO:0000313|EMBL:CAJ08001.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08001.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08001.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08001.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796430; CAJ08001.1; -; Genomic_DNA.
DR RefSeq; XP_001686384.1; XM_001686332.1.
DR AlphaFoldDB; Q4Q2R4; -.
DR EnsemblProtists; CAJ08001; CAJ08001; LMJF_34_2800.
DR GeneID; 5655053; -.
DR KEGG; lma:LMJF_34_2800; -.
DR VEuPathDB; TriTrypDB:LmjF.34.2800; -.
DR VEuPathDB; TriTrypDB:LMJFC_340037500; -.
DR VEuPathDB; TriTrypDB:LMJLV39_340033500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_340033600; -.
DR eggNOG; ENOG502SKGD; Eukaryota.
DR HOGENOM; CLU_431172_0_0_1; -.
DR InParanoid; Q4Q2R4; -.
DR OMA; CLTHIPK; -.
DR Proteomes; UP000000542; Chromosome 34.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR34157; TUZIN; 1.
DR PANTHER; PTHR34157:SF2; TUZIN; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 559 AA; 62176 MW; C796BC3548AD0843 CRC64;
MAVNAFFAKS ASAVLAPIAE GSIKSKIAGT VYAVHLQHLF LSPIIEVGSR VYIEYGKGEE
YAGAVVGGVV VRVNGNGTYG VLLDNNSFDM AVSADMVVFS EGRGKLASDA GHREVVEWLR
RAGVARRAHQ ESIACVLFHR GWRAHRLYLL QASDVHCLTH IPKAVRMRVL AESEWQRDHH
RQMRQLLKER VMERDFRYKL TKYSGVVSAS MALLGIAFAF GWNLKNSRTQ QREHQLKVAV
KALMQTLNQR HNTLQGTTSV AQHCVQRERE ESAVRQALRR LDVAHPRIIV FTGFRGCGKS
TLCRNAVLKE RMPAVYVDIR GTEDTLRSVA KALGVNRLEA CGDLLEFVAD TCRTAKAANG
DTPLLVLKLR EGSSFERVYN DAVALACDRR LCHVAIEVSI ESLSMATVAL PLLDFCMIAV
FSREQAFAYT QHTIDAVSLN HFVDIIGTNS NDVDELFAAV HQRRVSAATY TNEKLLKAMR
QLQATCAGRP QLRSALQQLS AVPYGEGQDV GGDAAALRSA ALRDIVLYDP VQDVWLFRNK
LFHSASRCCW PQTRGEMRR
//
