ID Q4Q4J7_LEIMA Unreviewed; 406 AA.
AC Q4Q4J7;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Putative serine peptidase {ECO:0000313|EMBL:CAJ05979.1};
GN ORFNames=LMJF_33_0400 {ECO:0000313|EMBL:CAJ05979.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05979.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ05979.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ05979.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796429; CAJ05979.1; -; Genomic_DNA.
DR RefSeq; XP_001685779.1; XM_001685727.1.
DR AlphaFoldDB; Q4Q4J7; -.
DR STRING; 5664.Q4Q4J7; -.
DR ESTHER; leima-q4q4j7; ABHD17-depalmitoylase.
DR EnsemblProtists; CAJ05979; CAJ05979; LMJF_33_0400.
DR GeneID; 5654429; -.
DR KEGG; lma:LMJF_33_0400; -.
DR VEuPathDB; TriTrypDB:LmjF.33.0400; -.
DR VEuPathDB; TriTrypDB:LMJFC_330010700; -.
DR VEuPathDB; TriTrypDB:LMJLV39_330010200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_330009900; -.
DR eggNOG; KOG1552; Eukaryota.
DR HOGENOM; CLU_678744_0_0_1; -.
DR InParanoid; Q4Q4J7; -.
DR OMA; HHGNAED; -.
DR Proteomes; UP000000542; Chromosome 33.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF204; ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN AHO-3; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 69..177
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 253..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 44663 MW; 9D41BB568A8A818F CRC64;
MLQSLVNSIV FVPPRDPNSL QRVQLLQRKR HMSFTSKKSG ERISYFHFDP KGDLVTKDNP
ERVVRSSMVL LFHHGNAEDL GSAFSYAQSM ACVFGVAVVV YDYCGYGFSG FPDAAKPAEV
TEKSVYSDAD HMYAHLLSLG YPAHRIIIVG RSVGGGPACY LAEKHHKKVG GLVLISTFTS
CLRVVSSCCL PYLCCCVDLF PNYRRIEHIM ECPVLVMHGT HDNVVPHHCS SELLEDIVAR
RNNALQRLLK KREGARANQA KRSSVLGAAS TGPTNTTTAS ATIIVADEAL VTAQPPLDGE
TVSVFDLYRR AYDGLPEAVR RVAEGRLDVT AADASIGVFH RWFAGCGHND IEAREGHAFS
DMFDYFVRFS TAFSMEREAL LLAKPVTGAA KASRDSLNRA DSEVRE
//
