ID   Q4Q4L1_LEIMA            Unreviewed;       366 AA.
AC   Q4Q4L1;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=Centrosomal protein of 19 kDa {ECO:0000256|ARBA:ARBA00022015};
GN   ORFNames=LMJF_33_0120 {ECO:0000313|EMBL:CAJ05853.1};
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05853.1, ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0000313|EMBL:CAJ05853.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2] {ECO:0000313|EMBL:CAJ05853.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000256|ARBA:ARBA00004120}.
CC   -!- SIMILARITY: Belongs to the CEP19 family.
CC       {ECO:0000256|ARBA:ARBA00009371}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FR796429; CAJ05853.1; -; Genomic_DNA.
DR   RefSeq; XP_001685737.1; XM_001685685.1.
DR   AlphaFoldDB; Q4Q4L1; -.
DR   STRING; 5664.Q4Q4L1; -.
DR   EnsemblProtists; CAJ05853; CAJ05853; LMJF_33_0120.
DR   GeneID; 5654352; -.
DR   KEGG; lma:LMJF_33_0120; -.
DR   VEuPathDB; TriTrypDB:LmjF.33.0120; -.
DR   VEuPathDB; TriTrypDB:LMJFC_330006400; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_330006500; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_330006400; -.
DR   eggNOG; ENOG502RYWF; Eukaryota.
DR   HOGENOM; CLU_757501_0_0_1; -.
DR   InParanoid; Q4Q4L1; -.
DR   OMA; TPRQWWC; -.
DR   Proteomes; UP000000542; Chromosome 33.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; ISO:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR   GO; GO:0034454; P:microtubule anchoring at centrosome; IBA:GO_Central.
DR   GO; GO:0097712; P:vesicle targeting, trans-Golgi to periciliary membrane compartment; IBA:GO_Central.
DR   InterPro; IPR029412; CEP19.
DR   PANTHER; PTHR31539:SF1; CENTROSOMAL PROTEIN OF 19 KDA; 1.
DR   PANTHER; PTHR31539; CENTROSOMAL PROTEIN OF 19K CEP19; 1.
DR   Pfam; PF14933; CEP19; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542}.
SQ   SEQUENCE   366 AA;  40692 MW;  4B2ED391517273E2 CRC64;
     MGVDDMGAEL WALVHHLFRK YRRDPRKAVQ ELALRTHAEW TSEPGVPLPT IALDVKESPW
     YHKMCSRHAS LLEELHAKHK RDIADAQELV SSLYPDGCNL SEYAEALRTS AALLPCLVPS
     DTIDHLIQKR GADFQEKGRH EVSNDELVSD VIEGLMIRVL TPRQWWCRGA SSVARATRTG
     IQSNPPTLYV EYERPAGVPH VRRIHLRTNL RPDMPTAQLA RRLAKTHEAL LSEAQFQSLL
     IRCQRLQGQS PVPSVATAPP TGTVAPTAIA ALLPTIANTS SPDAPTARSG KPQKADLGLL
     YRDPDAALEN VDLNDADEVT LQEFKEVMNE RFKAKVVKPG DPGYVYDKRV EVSKPTQSSG
     WDDDSD
//