ID Q4Q5J0_LEIMA Unreviewed; 893 AA.
AC Q4Q5J0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=LMJF_32_0920 {ECO:0000313|EMBL:CAJ08612.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08612.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08612.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08612.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; FR796428; CAJ08612.1; -; Genomic_DNA.
DR RefSeq; XP_001685408.1; XM_001685356.1.
DR AlphaFoldDB; Q4Q5J0; -.
DR STRING; 5664.Q4Q5J0; -.
DR EnsemblProtists; CAJ08612; CAJ08612; LMJF_32_0920.
DR GeneID; 5656205; -.
DR KEGG; lma:LMJF_32_0920; -.
DR VEuPathDB; TriTrypDB:LmjF.32.0920; -.
DR VEuPathDB; TriTrypDB:LMJFC_320016400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_320014900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_320014900; -.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_2_1; -.
DR InParanoid; Q4Q5J0; -.
DR OMA; HYVIHTI; -.
DR Proteomes; UP000000542; Chromosome 32.
DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 414..437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 458..476
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 543..562
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 574..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 636..660
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 832..855
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 707..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 101371 MW; F739C84138C7A9F3 CRC64;
MPWHQEQCSG LWRSEDMIRV NIILQREVLH DTMYEVGMLG CVQFLDMNEG VTAFARPFTE
ELRRCEELQR KLHFIEESMC KDADLLERYP EDVHMSATVE EMRSSLLRGQ MHMIDDRIES
TVNELTAMLT SLEGFQHEMN QNQEMALLYY KYRLLVETPC DMAASNSSYA HHGAAVSSEA
FSRLASLFGF IDSKLSEELY RLCYRITRGN AIVEISNEPA MFVDVQTGER NVAKTSFMVL
CASPTMITRL KKLMIGLGAD VYTLDEVQSR GIELTTSTTA HHVEDTIEGV ERRKRDVLTL
WYEEHRLYKT YLKVEKVVLT AMNTCAMSGS TCTASAWVPL RHEQSLRRAL QDAVASANGS
VESIVTLHAE QKHPPTFFET NRFTESFQGI VDSYGMARYK EVNPGVFTII TFPYLFGIMY
GDIGHGFLLL FIALFFISKE KAWRTAQLNE IVAMAFGGRY LLLLMSLFAI YMGVLYNDFF
GFSLNLFSSG YTWAPISEQK GTTYPTTPNG LPSVKPPRVY AMGLDAAWAE TDNKLEFYNS
VKMKHAVIVG VAQMFAGLFL SLNNSIYEKN WYKIAFLFVP EFVFLLCTFG YMSILIMVKW
CRTWENTNKA PSILEIMTNF FLQPGSVPNP LFGGQAGLQV FLLLAAFAMV PFMLLGMPYI
EMRDYKRWQR RRQVWGSRRR HGRALRTSVV TIENSDYTDA FLNEPSASLQ HRQTSDSGDE
SAHRNLMSDD DETANIFGDD NMHPFGVPAA SSEEGSTATV IERENEKFEH FDVSELIIHY
VIHTIEYVLS SVSNTASYLR LWALSLAHSQ LSEVFFSFTV AKTLDIDNSS GFVIAIGVLL
WIGTTLGVLV GMEALSAFLH ALRLHWVEFQ NKFYAGDGRA FDPLDLTNLN TAN
//
