ID Q4Q648_LEIMA Unreviewed; 929 AA.
AC Q4Q648;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=tRNA ligase phosphodiesterase domain-containing protein {ECO:0000259|Pfam:PF08302};
GN ORFNames=LMJF_31_2130 {ECO:0000313|EMBL:CAJ08402.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08402.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08402.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08402.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796427; CAJ08402.1; -; Genomic_DNA.
DR RefSeq; XP_001685200.1; XM_001685148.1.
DR AlphaFoldDB; Q4Q648; -.
DR EnsemblProtists; CAJ08402; CAJ08402; LMJF_31_2130.
DR GeneID; 5654145; -.
DR KEGG; lma:LMJF_31_2130; -.
DR VEuPathDB; TriTrypDB:LmjF.31.2130; -.
DR VEuPathDB; TriTrypDB:LMJFC_310035200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_310030200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_310030200; -.
DR eggNOG; ENOG502R07Z; Eukaryota.
DR HOGENOM; CLU_336684_0_0_1; -.
DR InParanoid; Q4Q648; -.
DR OMA; AHYPCAN; -.
DR Proteomes; UP000000542; Chromosome 31.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IBA:GO_Central.
DR GO; GO:0003972; F:RNA ligase (ATP) activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015965; tRNA_lig_PDEase.
DR PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR Pfam; PF08302; tRNA_lig_CPD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 846..901
FT /note="tRNA ligase phosphodiesterase"
FT /evidence="ECO:0000259|Pfam:PF08302"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 103287 MW; 246A6B3CB1861198 CRC64;
MRDSSRGSSG RGGRSRRGSR ARQGRGGGGR GPSSSSRPPT ASPNMSQGKS EQTEHDVESI
AIPNAFDASC AHVSRCREKG RLLRLPPPAA AAAAQCNFVV VERTISGMDE VVYSRHRDVW
ERLPQGNARV YVESDSSNGT PTYSLVGAID GLRKFGCKDS TYGYPDALQT VIAMEEENGE
CGHLSAFVVP PAKRGEQSTT SQASCDAANE EDTSRRFWVI GSKDVHIVLD YAVSEECLHY
YSSLGCRYSQ AVKISRLWKA MLPGGGASSG CGGGGGSTPS SANADARAAA FRTLTPAQAR
AFHETLYKKM WTSCFVAIFS DSQYLMEDSG TNELRFYAVT LSKRAFEAAR TGRTDLSSNK
APEREDGDCQ EETADAQNEA QQYSQQDGLC IPVAEAEALC AGVGLAFSRY SAPVMYGSPE
YVQRIRTINR RIDLEGCVMY GADASGKVVR LWKEKAYPYA MERATREAVT NHKLNGNDLQ
VWLKKKLDQQ RPELRDHFKE WEANRMPWLL HFAAWLQMTQ RLTPDMQRNE LFQLRKEWRS
LQKAFQTVID SDPKLRDACG QYRPDPVQWG SGTHDLDVIK FVGPQGSGKS TLSRALYVLL
QTSRCQPRWV NQDESGKRNK FLASLRQATQ AESTVTHLII DKMNLDAKMN HDYDNLPLSL
TVTWFHPDGE KALYDVCIAR VLGRGNGHRS IRVDPNRTLQ EREEQVQRTR SFVRKAVRDF
ETPKDPPELL LELDITSPLH DMVLMMWEKL QANGTHTLRP VTDEDVSEAI SLAHQYELYL
HNLPRPPTYA CISIANQQDV EKLLKLVPPE LTAGQVVQRE FHVTTQYFGG KIDPVAFVAL
AKLLGQSVTL TLESVVADAD GVAITVRRDD AHYPCANPIP HITISNRKGV PPKYSNDLIS
PTAYPGDPAK RKVLPLPPNC TVMGVFEFR
//
