ID Q4Q9J4_LEIMA Unreviewed; 327 AA.
AC Q4Q9J4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Tagatose-6-phosphate kinase-like protein {ECO:0000313|EMBL:CAJ05648.2};
DE EC=2.7.1.144 {ECO:0000313|EMBL:CAJ05648.2};
GN ORFNames=LMJF_25_2440 {ECO:0000313|EMBL:CAJ05648.2};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05648.2, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ05648.2, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ05648.2, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796421; CAJ05648.2; -; Genomic_DNA.
DR RefSeq; XP_001684004.2; XM_001683952.2.
DR AlphaFoldDB; Q4Q9J4; -.
DR STRING; 5664.Q4Q9J4; -.
DR EnsemblProtists; CAJ05648; CAJ05648; LMJF_25_2440.
DR GeneID; 5652727; -.
DR KEGG; lma:LMJF_25_2440; -.
DR VEuPathDB; TriTrypDB:LmjF.25.2440; -.
DR VEuPathDB; TriTrypDB:LMJFC_250035800; -.
DR VEuPathDB; TriTrypDB:LMJLV39_020005100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_020005100; -.
DR eggNOG; ENOG502S83D; Eukaryota.
DR HOGENOM; CLU_050013_0_2_1; -.
DR InParanoid; Q4Q9J4; -.
DR OMA; QMIAHAG; -.
DR Proteomes; UP000000542; Chromosome 25.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009024; F:tagatose-6-phosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR017583; Tagatose/fructose_Pkinase.
DR PANTHER; PTHR46566; 1-PHOSPHOFRUCTOKINASE-RELATED; 1.
DR PANTHER; PTHR46566:SF2; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE ISOZYME 2; 1.
DR Pfam; PF00294; PfkB; 1.
DR PIRSF; PIRSF000535; 1PFK/6PFK/LacC; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAJ05648.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ05648.2}.
FT DOMAIN 26..298
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 327 AA; 34911 MW; 5F82F818356B969B CRC64;
MGSPLIAVIG PNPAFQKTLA FDELRVDEVN RAATVHSYTG GKGTNFCRAS ACCKESPHFC
RTTLHTFVGG KTGERVIDLL HQEGIAVYPV TVPAETRTCI TCLDTQNSTM TELIEPSAAV
PDDAAKDMDR ALLKALEHAG GMAIMGSLPD GSSPDLYTRW TEMAAAAQKP VLIDAVKGIE
ASLKVPGVHS ILKVNMRELN KLTGQSTPES AFEYAMQMWT VRVLAVTDGP RSAYIQERGQ
PLQVVHIPKV DGVVSPLGAG DTADAIFLAK YIHGTTPVEA FRLALAAASA NCLQKEAGVF
AQHEMRRIAD GITIGSSRPH SSSNTRA
//
