ID Q4QAG2_LEIMA Unreviewed; 379 AA.
AC Q4QAG2;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=SET domain-containing protein {ECO:0000259|PROSITE:PS50280};
GN ORFNames=LMJF_24_1690 {ECO:0000313|EMBL:CAJ05190.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05190.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ05190.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ05190.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796420; CAJ05190.1; -; Genomic_DNA.
DR RefSeq; XP_001683686.1; XM_001683634.1.
DR AlphaFoldDB; Q4QAG2; -.
DR STRING; 5664.Q4QAG2; -.
DR EnsemblProtists; CAJ05190; CAJ05190; LMJF_24_1690.
DR GeneID; 5652341; -.
DR KEGG; lma:LMJF_24_1690; -.
DR VEuPathDB; TriTrypDB:LmjF.24.1690; -.
DR VEuPathDB; TriTrypDB:LMJFC_240025300; -.
DR VEuPathDB; TriTrypDB:LMJLV39_240024500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_240023800; -.
DR eggNOG; ENOG502QUIU; Eukaryota.
DR HOGENOM; CLU_730492_0_0_1; -.
DR InParanoid; Q4QAG2; -.
DR OMA; RSMLNHS; -.
DR Proteomes; UP000000542; Chromosome 24.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR CDD; cd20071; SET_SMYD; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF305; SET DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00856; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 105..348
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 379 AA; 42092 MW; FDA47EC809F20DD2 CRC64;
MSVNAIKAAW HGAAELKRHC NHVINTLGPQ TPPEAFLYRG NAYYALGQPY FALADYNTAA
SVLRLSGEHQ RRCSKALESF PATQTGVYPS TDSHLHIFVK PMLSKSCAIE TVNEHVGRGV
RATENMPRNS VVVQPTSPWL LYPTDEGLCS YCGTSLPERH FACTNDDCHE EYCSRDCRQE
AMAHYHAAVC RNKDYQSIEL DVFAQMTEAA KAGAVAERNA AAAQLLVLRV LSTGMQKHVV
PSAMGQVRIL SGRLTFSPQV LAGSMLHLYE RLTRALHIAT IVPYEEMIGV LARITANCFH
RDGTVELNLP RSMLNHSCAA NVAEDGQTGA MITTRDVARG EELVINYYPL LKDLPYAERT
AELERRGFRC MCAKCQRRE
//
