ID Q4QAG5_LEIMA Unreviewed; 518 AA.
AC Q4QAG5;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=tRNA/rRNA methyltransferase SpoU type domain-containing protein {ECO:0000259|Pfam:PF00588};
GN ORFNames=LMJF_24_1660 {ECO:0000313|EMBL:CAJ05174.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ05174.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ05174.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ05174.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796420; CAJ05174.1; -; Genomic_DNA.
DR RefSeq; XP_001683683.1; XM_001683631.1.
DR AlphaFoldDB; Q4QAG5; -.
DR STRING; 5664.Q4QAG5; -.
DR EnsemblProtists; CAJ05174; CAJ05174; LMJF_24_1660.
DR GeneID; 5652338; -.
DR KEGG; lma:LMJF_24_1660; -.
DR VEuPathDB; TriTrypDB:LmjF.24.1660; -.
DR VEuPathDB; TriTrypDB:LMJFC_240025000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_240024200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_240023500; -.
DR eggNOG; ENOG502RX7U; Eukaryota.
DR HOGENOM; CLU_526258_0_0_1; -.
DR InParanoid; Q4QAG5; -.
DR OMA; TTEQACV; -.
DR Proteomes; UP000000542; Chromosome 24.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR43191; RRNA METHYLTRANSFERASE 3; 1.
DR PANTHER; PTHR43191:SF2; RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 285..469
FT /note="tRNA/rRNA methyltransferase SpoU type"
FT /evidence="ECO:0000259|Pfam:PF00588"
FT REGION 18..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 54837 MW; D9B8E943F93CCC96 CRC64;
MIALSRCCLR YVPRRPPAFG TVVGGGTRPR RTGAPAPRQR NQETAANTET VAEAEVVAAS
TSTWEDAKRA AADLPHRTQT SPPPHLQPHR AAASTSLPPH QRFRTLSKPV VLEGVQDTYA
ITPTQEVHGQ QLWTATKVLR SSKHIRKADA TCVVGGASAI RRIWRTYNIR PNVVYVPNTD
SGVPAWCLEE ELPTVIVRCS PVAVRRHLLS AEYSDGYAAE FPLPVNCIRD ATALLAPPPV
PAQSETAVPS TGDASSSLSS KLSATGPPAA HPLHDPFGHH AVGAMLVLVG LRIPSNVGTL
LRAAADMGYD AAVLVSCADP TQEKVLRASD GTALSPTLRI YETETTEQAC VSLLSSIAAQ
HNLMPFLAVP SQEVEPAFEV AKRFHVYNAK NKEASTSQVG GGAAAGHSDG LCAPPPRQLG
AMVILGSEAQ GLRDLNGRWG VPYQLVTLPL PNPVVDSFNV SVAGSVLMHL FRPSAASHFT
RLVALSGEAV GDLLPTPVGD DDGSDKHAET DEAEASPL
//
