ID Q4QAT5_LEIMA Unreviewed; 276 AA.
AC Q4QAT5;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 102.
DE SubName: Full=Putative ubiquitin-activating enzyme {ECO:0000313|EMBL:CAJ04249.1};
DE EC=6.3.2.19 {ECO:0000313|EMBL:CAJ04249.1};
GN ORFNames=LMJF_24_0460 {ECO:0000313|EMBL:CAJ04249.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ04249.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ04249.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ04249.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796420; CAJ04249.1; -; Genomic_DNA.
DR RefSeq; XP_001683563.1; XM_001683511.1.
DR AlphaFoldDB; Q4QAT5; -.
DR STRING; 5664.Q4QAT5; -.
DR EnsemblProtists; CAJ04249; CAJ04249; LMJF_24_0460.
DR GeneID; 5652212; -.
DR KEGG; lma:LMJF_24_0460; -.
DR VEuPathDB; TriTrypDB:LmjF.24.0460; -.
DR VEuPathDB; TriTrypDB:LMJFC_240010400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_240010100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_240009700; -.
DR eggNOG; KOG2018; Eukaryota.
DR HOGENOM; CLU_013325_4_1_1; -.
DR InParanoid; Q4QAT5; -.
DR OMA; DMDDICV; -.
DR Proteomes; UP000000542; Chromosome 24.
DR GO; GO:0005634; C:nucleus; ISO:GeneDB.
DR GO; GO:0061503; F:tRNA threonylcarbamoyladenosine dehydratase; IBA:GO_Central.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0061504; P:cyclic threonylcarbamoyladenosine biosynthetic process; IBA:GO_Central.
DR CDD; cd00755; YgdL_like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR43267; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR PANTHER; PTHR43267:SF1; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:CAJ04249.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 9..246
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REGION 192..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 276 AA; 29900 MW; F2CE6BF90829ADAB CRC64;
MLNSALYERT QILIGDDGIR SLQNTNIFLA GTGGVGGHCA EALVRAGVGS ITIVDYDVVT
SSNKNRQLIA LDSTIGKSKV EELARRLRDI NRHCVIVALD AFITSEDAEE VLSRQRYDFM
VDCIDSVTCK VALLAAAVKL KIRAYSSCGA GGRIDPSLVS IGDLFSTEND GLARACRAAL
RKHGVGPGDV TVVHSSEKGI PPLKPQRQEA GGRDRSMNGT ISHMPPLFGL MLASAVLRCA
VNPAAHDAEV EQRRKRERKE QKRALKKRRK ETPPTT
//