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Database: UniProt
Entry: Q4QAY7_LEIMA
LinkDB: Q4QAY7_LEIMA
Original site: Q4QAY7_LEIMA 
ID   Q4QAY7_LEIMA            Unreviewed;       775 AA.
AC   Q4QAY7;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   07-JUN-2017, entry version 64.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=LMJF_23_1510 {ECO:0000313|EMBL:CAJ05081.1};
OS   Leishmania major.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0000313|EMBL:CAJ05081.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M.,
RA   Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K.,
RA   Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A.,
RA   Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C.,
RA   Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D.,
RA   Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L.,
RA   Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S.,
RA   Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H.,
RA   Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B.,
RA   Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J.,
RA   Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D.,
RA   Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S.,
RA   Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C.,
RA   Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S.,
RA   Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.,
RA   Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2] {ECO:0000313|EMBL:CAJ05081.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; FR796419; CAJ05081.1; -; Genomic_DNA.
DR   PIR; T46719; T46719.
DR   RefSeq; XP_001683511.1; XM_001683459.1.
DR   ProteinModelPortal; Q4QAY7; -.
DR   STRING; 5664.LmjF.23.1510; -.
DR   EnsemblProtists; LmjF.23.1510:mRNA; LmjF.23.1510:pep; LmjF.23.1510.
DR   GeneDB; LmjF.23.1510:pep; -.
DR   GeneID; 5652160; -.
DR   KEGG; lma:LMJF_23_1510; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   HOGENOM; HOG000037059; -.
DR   InParanoid; Q4QAY7; -.
DR   KO; K02154; -.
DR   Proteomes; UP000000542; Chromosome 23.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000542};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    368    401       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    413    438       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    511    532       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    538    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    602    624       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    709    731       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       56     83       {ECO:0000256|SAM:Coils}.
FT   COILED       95    136       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   775 AA;  87599 MW;  888509F610D202FC CRC64;
     MPREACSGLW RSEDMVVLSL HMQREVAHDA VLKLGEIGQF QFEDLNKDVS AFQRDFVQEV
     RRCDDMERKL RFLQEESEKA GVATIVDGDA EGETMSSLEH KIDEVYSEVV ELNEQYQALI
     EERNRSKEHL EILSRDFGGA TGDGVLMVTG VIPKERIPLF ERLVYRATRG NSIMRTDNID
     KPFYNINANE PVYKSVFAVY FSAPRLHERL IKIAEANAAT VYNYADSEQQ LTRMHASLQQ
     QVDTITQTLN QSAYRQRQVL LGIAAVCYEW RRAVVTEKAV FSTMNMLKFS GSTAIARGWA
     PVRSCEDIRT AIAEAEYLSG AQVATIIEEL NTKETPPSYF KTNKITGSFQ SIVDSYGMAR
     YKEANPGVFT IITFPYLFGV MYGDVGHGII LTLFAAFLVF KEKSFEGQPL NEIFAMIFGG
     RYLLLLMGFF AVYMGLLYND MFGFSIEIFA SGYRWPQLPP EGPDGIVYPS FPTGRPSVKP
     ESSVIFGIDS AWSETENKLE FYNSIKMKCS VIIGVAQMMA GVLISLTNYI YFNDSVKVWF
     RFVPEVVFLS CTFGYMCVLI IVKWLTTWEN THDAPSLLET MTNFFLAPGT ITLPLFSGQA
     ALQVMLLLVS LACVPCMLCV IPYVEKKEHD QKMQERAAHP PADGEEEGED DFQLSEIIIH
     QIIHTIEYVL GCVSNTASYL RLWALSLAHS QLSEVFWSFA FLLTVDYDSG TGICIFFGFA
     MWMTATIGVL LGMESLSAFL HALRLHWVEF NNKFYAADGY AFEPFDLAET LSKLR
//
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