ID Q4QDJ3_LEIMA Unreviewed; 633 AA.
AC Q4QDJ3;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Putative sarcoplasmic reticulum glycoprotein {ECO:0000313|EMBL:CAJ07113.1};
GN ORFNames=LMJF_19_0280 {ECO:0000313|EMBL:CAJ07113.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ07113.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ07113.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ07113.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}.
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DR EMBL; FR796415; CAJ07113.1; -; Genomic_DNA.
DR RefSeq; XP_001682605.1; XM_001682553.1.
DR AlphaFoldDB; Q4QDJ3; -.
DR EnsemblProtists; CAJ07113; CAJ07113; LMJF_19_0280.
DR GeneID; 5651127; -.
DR KEGG; lma:LMJF_19_0280; -.
DR VEuPathDB; TriTrypDB:LmjF.19.0280; -.
DR VEuPathDB; TriTrypDB:LMJFC_190008500; -.
DR VEuPathDB; TriTrypDB:LMJLV39_190007700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_190007600; -.
DR eggNOG; KOG1954; Eukaryota.
DR HOGENOM; CLU_029311_0_0_1; -.
DR InParanoid; Q4QDJ3; -.
DR OMA; LMIGQYS; -.
DR Proteomes; UP000000542; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR CDD; cd09913; EHD; 1.
DR Gene3D; 1.10.268.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR040990; DUF5600.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR031692; EHD_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43681:SF1; SARCALUMENIN; 1.
DR PANTHER; PTHR43681; TRANSMEMBRANE GTPASE FZO; 1.
DR Pfam; PF18150; DUF5600; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF16880; EHD_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 62..305
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT REGION 437..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 69135 MW; 55102139F0CBC8F9 CRC64;
MSISGAAAPA PLRGRESGGN VPGSMGALIK KLHPLYTQRV RPLEEMYSFD VFRPSWYEET
ILNERPFITL FGPWSAGKTT FINYLLQSND LWTGPQPTTA EFTVVMYGKE PGPVAGQALA
NSKHLPFKGL LDFGESFIRN LKGFQAPHAL LERVTLIDTP GVLESAKDIH QRKYDYVNVC
RWFAERSDLI FVFFDPSKLD AGGELRQLFQ TSFKGFENRL RLVLNKADTI STQELMRVYG
SLFWNLSNFI NTTEPPRVYV GSFWDKPYSP NSFSRLFAEE KLDLLHELLE VIPQQARDKK
VASLIRRAKE VLVHAVILGG IRADLPLLFG KSKAKKKAAE QLPRRYELIG ARYKMNHRDF
PPVQAYRSFL ERFDVAKFPP LQKAEKAGLI RGIQELIDTI LPSMLRPVCN TRAANPFEED
KQTGLLSMYR DHVLLQRDGR PGMQGGTDKV ASTMGQGVPD SATTGPSSSV AAAPASGPSS
LLGPGPAVTA LSASPPFIEL PSRAMAASST AVAASSPPPP PPSSAAATSS PADMQAMMAI
MQQMVAYQQQ QQQQQDRQSS SAPATVNSHG TLSSSSSETS GCLAESSVPV TPQESNLNSE
PQPPTVVPQL GLPNSCATQI SAWAGGDESK SQH
//
