ID Q4QDQ2_LEIMA Unreviewed; 823 AA.
AC Q4QDQ2;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE SubName: Full=Putative heat shock protein {ECO:0000313|EMBL:CAJ04184.1};
GN ORFNames=LMJF_18_1370 {ECO:0000313|EMBL:CAJ04184.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ04184.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ04184.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ04184.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796414; CAJ04184.1; -; Genomic_DNA.
DR RefSeq; XP_001682546.1; XM_001682494.1.
DR AlphaFoldDB; Q4QDQ2; -.
DR SMR; Q4QDQ2; -.
DR STRING; 5664.Q4QDQ2; -.
DR EnsemblProtists; CAJ04184; CAJ04184; LMJF_18_1370.
DR GeneID; 5651068; -.
DR KEGG; lma:LMJF_18_1370; -.
DR VEuPathDB; TriTrypDB:LmjF.18.1370; -.
DR VEuPathDB; TriTrypDB:LMJFC_180022000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_180019100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_180019400; -.
DR eggNOG; KOG0103; Eukaryota.
DR HOGENOM; CLU_005965_5_1_1; -.
DR InParanoid; Q4QDQ2; -.
DR OMA; WEQSPEI; -.
DR Proteomes; UP000000542; Chromosome 18.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd10228; HSPA4_like_NDB; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR45639:SF4; HSC70CB, ISOFORM G; 1.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Stress response {ECO:0000313|EMBL:CAJ04184.1}.
FT REGION 526..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 91804 MW; 90681362E05CCDE4 CRC64;
MSVFGIDFGN VNSTVAITRY GGVDIVTNEV SKRETTTIVS FVDDERFIGE QGLDRYVRNA
QNTVFLLKRF IGMRMDDSQL SRELKFLTCN IIGDTSGRLM FSVNYCGEEK HFYPEQVLAM
MLQRLRSYVN EAATTDPRVK ADVRDFVITV PCYYTAEQRR LMYQAAEVAG LHCMSLINET
TASAVDYGIF RGASLKETME EGQVVGILDI GYGATVFSVC KFWRGNCKIL ARTFDRNTGT
RDCDYLLYEH MLNEVKSRYN VDVSQNKRAR LRLVQACERL KYLLSANQSA PLNVENLMDI
DVSIPVFERA TMESLCQDVL HSIKLVIERG FAEAGVNRDD FHSIEMIGGG CRIPMMKRLV
EEVLGRGPSF TLNASESTAR GCAIVAAMLS PKFQVREFKV SELPTYPILL GYHAENPRSP
SSVPFLPQVN KVVKLLGAAD SYPKKLDVRF PCSSAPKIYA FYDYENEGVK EIVQPCNYII
GEWEMGLPSK AKGAVNEMRV RICIQPDGVV ELEKAEAIDV YEVEEAPDAA PAAENGEGPE
KENEEALAEP PKPVKPVKKT KEAAIVVSVK PNVEILGHSG ESVLVFRKAE AEMCERDCRI
VRTRIKKNEL ESYILDFRPR LSPGGMLIEY AAPDAAANFV RQCDEDEQWL YEDGEFSTFE
EYERRVQALR AIGDAAYNRL RTREDVEFAA KGVQTRIMAA QQKALDLIGK KEHITEEELK
EAAATAEQAK AWVDQQVAAM LAAPKTQDTM LSKADLEKKA SEVEQGIHKV MTKPAPPKPK
ESKKPENAEE DVAAEAAAGA EAAPQQKAPE EEVPAPTNAP ELD
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