ID Q4QDV2_LEIMA Unreviewed; 874 AA.
AC Q4QDV2;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=Putative dolichyl-P-Man:GDP-ManGlcNAc2-PP-dolichyl beta-1,4-mannosyltransferase {ECO:0000313|EMBL:CAJ03816.1};
DE EC=2.4.1.83 {ECO:0000313|EMBL:CAJ03816.1};
GN ORFNames=LMJF_18_0900 {ECO:0000313|EMBL:CAJ03816.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03816.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03816.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03816.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
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DR EMBL; FR796414; CAJ03816.1; -; Genomic_DNA.
DR RefSeq; XP_001682496.1; XM_001682444.1.
DR AlphaFoldDB; Q4QDV2; -.
DR STRING; 5664.Q4QDV2; -.
DR CAZy; GT33; Glycosyltransferase Family 33.
DR EnsemblProtists; CAJ03816; CAJ03816; LMJF_18_0900.
DR GeneID; 5651018; -.
DR KEGG; lma:LMJF_18_0900; -.
DR VEuPathDB; TriTrypDB:LmjF.18.0900; -.
DR VEuPathDB; TriTrypDB:LMJFC_180015700; -.
DR VEuPathDB; TriTrypDB:LMJLV39_180014500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_180014400; -.
DR eggNOG; KOG2941; Eukaryota.
DR HOGENOM; CLU_328857_0_0_1; -.
DR InParanoid; Q4QDV2; -.
DR OMA; ATRINEH; -.
DR Proteomes; UP000000542; Chromosome 18.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:GeneDB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:GeneDB.
DR GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; ISO:GeneDB.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR InterPro; IPR026051; ALG1-like.
DR PANTHER; PTHR13036; BETA1,4 MANNOSYLTRANSFERASE; 1.
DR PANTHER; PTHR13036:SF0; CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:CAJ03816.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ03816.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 60..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 874 AA; 94535 MW; D5759F7B3F4754D6 CRC64;
MFQYEDLMWL ISFPLVCAIM LWFSLDLAVL VRVGGGRRRR ANARRAIERL IMSSPVLTTA
SVVPSPSPVS TPDTDRPSRR RSSSASPEHA CMGGLGSSSG NEEGHGVKHR AASAGAAGTP
TAGTIPCHQQ RVRQVVVPAA LRIATRAVVR RAVVLVGGDF ARSPRMQYHA ASLARSSLFD
EVLLVGLDYG NQLSEDLLMS GEPKPERFVS WDDPATPKGM EHAVFDVQAR LDSPDPGPGR
GCIVSTQYLI APPSPPEWLQ TVFPLIHLHW VVCTLYRIVT LTGLFFFQTM CATATRINEH
GQLLVTDLIL IQTPPAVPFV LLVKYLVCPL AFVYNMLLYY GVVVPAAWMN PGAMRDVRQQ
CKLQSLHFTS ATECSADGRQ RALAILHGLA HASLSGKRRW VFYPAIVVDW HNFGYTILAQ
NQRPTAAVKV YQLLEMHMCA GHVNVTVSQA MRRALEHAYP WLRCESAITA AAGVQPHCSA
SAAASASLQA EGAPSVAAVL PSAVTVLYDV APSFFRPVQR SRCVRDVLER LLRRRHRAVG
PSPPLASASP LAKGTGNGAA YALVSKADLE EMGWGIAGPP AWVYADAAAE SVAVSALPTP
AAAPATMAAV LRRGIMVVGS TSWTEDDDYS MLIQALQRLD HRLRHEVSYR SSNGEGSLSA
SSGPADLWVL ITGKGDTRQR FEDAVRVAKL SSHVVVSTYY AQSYQEYSLL LGAADVGLCL
HFSSSGLDLP MKGVDMVGSG LPIMAMQYPA IGELIGGVTR VLATQAMRLR NGAADAQGTP
RVSSGYAKAV QPTLHECERG WSFSNDADLE FLLSSFIGLP STSESVGDGA SSLSRSPPTP
LSVMKQRAYE ARRHAHTWEQ NWRRVLLPVL KQVV
//
