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Database: UniProt
Entry: Q4QEZ2_LEIMA
LinkDB: Q4QEZ2_LEIMA
Original site: Q4QEZ2_LEIMA 
ID   Q4QEZ2_LEIMA            Unreviewed;      2874 AA.
AC   Q4QEZ2;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   07-JUN-2017, entry version 68.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAJ03464.1};
GN   ORFNames=LMJF_16_0280 {ECO:0000313|EMBL:CAJ03464.1};
OS   Leishmania major.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0000313|EMBL:CAJ03464.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M.,
RA   Cadag E., Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K.,
RA   Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A.,
RA   Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C.,
RA   Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D.,
RA   Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L.,
RA   Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S.,
RA   Mottram J.C., Muller-Auer S., Munden H., Nelson S., Norbertczak H.,
RA   Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B.,
RA   Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J.,
RA   Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D.,
RA   Schafer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S.,
RA   Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C.,
RA   Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S.,
RA   Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.,
RA   Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2] {ECO:0000313|EMBL:CAJ03464.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural
RT   change between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796412; CAJ03464.1; -; Genomic_DNA.
DR   RefSeq; XP_001682106.1; XM_001682054.1.
DR   ProteinModelPortal; Q4QEZ2; -.
DR   STRING; 5664.LmjF.16.0280; -.
DR   EnsemblProtists; LmjF.16.0280:mRNA; LmjF.16.0280:pep; LmjF.16.0280.
DR   GeneDB; LmjF.16.0280:pep; -.
DR   GeneID; 5650573; -.
DR   KEGG; lma:LMJF_16_0280; -.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   HOGENOM; HOG000256415; -.
DR   InParanoid; Q4QEZ2; -.
DR   Proteomes; UP000000542; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000542};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2402   2421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2441   2467       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2527   2549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2570   2594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2657   2676       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       79    136       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      205    258       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2851   2874       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2874 AA;  316810 MW;  8581208606C5323C CRC64;
     MATKENAGQN MLVQPLRYGS LISLYKQSLD GYVVATSSSE APVGLQRDTP ETPLRHEHTV
     LLLQRGDPAE ANVNRQPDSD VVKYGQTIRL LHYAHQKYLS YHAERYAAGM KGNHHVLLET
     RRRDANVRER WRIMPRYRLR VEGEPVAAGD AIILQAVETE RYLNVAPNVD EEAADNWFLE
     VSVGESIQGF LIHLYDGDCA ASRRGPPLRC GDCVTLLHTE EHKYVLADPV KQQCVLQTPD
     SNLAEGSEHT VAWYAASKEE VSYLSLFVIE GANASKGGAL RMRGAGDAYR FKSLASGLYL
     QCGEVAAVEP TEGGGAGLGR GARQASYALS LTPHARSAGT LFQLHCTSSN AEEFLGNGGR
     VFLSCVNSAN QKVWVVAGGP VAAEGEDVRH SEVTIASLTH GVRTYGVVTL LGSGFKSMRD
     GLEIRRLQPI ALEELHMIRR LLPPLQRYVR EMACGVGSPH HVRQAREKVQ QLQQLCHRPA
     DPDAENVSEE LMNSGSAGGG RGGVLNPEWQ SKVFQQGVGE LVLLVVRASL QCPYVHAEKL
     GSLGMVYPQA GCNNGADSVA AASSFGAAAG GADVASAPSA ASASGGLSLF VPMRYSELGD
     LVDACFELVG VLFYNRPRYA AALQSYADFV MECTRYVPSA LRCLAAFYKD NPALVELPMA
     RHRLEFFLEM LASRGYNPDV LHILRRFACC GGEGMVEAQR VILDYFTQNR EMTQRVLCPM
     KWMPLPEELE TTRIAQMPRA QATSSALATA VKEQKGLVAE GGPTCVELAD TLCQLSAALF
     TDTREASVAG TVPEGECNAS IGAASRQAPL STASILPPCS PAAAAPELST SVRAVREMPM
     VGIPNLLFEE PEFSDSASLA TSTQYRAKGN PLSQLLQKAV DAQDVNGTTY FPLEGLLAVM
     PDWPEVRDTL VPYLAAQIHL LAALAYGEGH ARSRPFILEW VPRAVLVELL QSEVLPRRLH
     GALVELFAKV MVDADGALNI REQIQNIWCV VSLPGGGCSA TGATSAAVAS SCQMAMHKVP
     RELEVAKGFV VRYMTATRMS GDDSVAAEYL AALNLLDELV NAGAFQLSEY ETLMRLLVRC
     VDPSCDAQHT VLEMQPVQDC KSRVLQLMNL LIDVLLVREA LWLVDCFRMW RRPTRFSQLT
     HINFAAALPQ RSTEKWRATD GGGDEADEEQ DRRADVACDC DLDGVYNEEE REPREELIPI
     AEAFTALMEL ANCSRSSMLQ RQVICIFFRA TNFLEELYAT ASRVQLLTSE DSIGFYAAIN
     RTSIVVKQLA KASFRRTNTI ALANSALDAL DDLLLKPKSG TVAEKLSMMQ QVGVPLQLIR
     MLERVSVPVS AASRQLVVKT VAILQTMAQS PRVCDELREA VVGAAPLAYQ NTNYISLLRT
     LFVAEDDGRT EMPTQILADV VRCLYREHAA LTAIEFLSDW MAAKRSSVHV MAQRQQQVWR
     AIVSDQQAER CIQLRRSWCS NQGHKLRERL LTSDDCYAVT GRTRTHLDLC RLLYLVANKS
     EFVKAEAVRQ EVFGQNSLDA LLQVTTDVLV PVYFRYPYVQ LLQALVLDDA CAVPSLLAHR
     DFPDFVRLCM MDAARYLQLL GGRCALDEVS EELEQREGAT LRCAPKNEAE EEMEEALFGA
     GMYEDFFFGP LCACTERVCA RYRSCTSQLS NRVRSQLSVV VNELVDAMCD VLQLFFNMED
     GILRGAPHSA AGLPSPTTAP FPEVPWSLAH FTALRQCLRV AKDSGFSGTA RWRGGPFSRL
     CARLAAYVEA AAKPPNPATA AVSGESAAVV TPGVVLKGGD SCAWNSHIEA GGGAHVLASK
     WMDYLRSVLA DDARMAEKNR LISGAGILLR CGARGATFMR ILFTVMPSLQ HPNIVHVLTL
     TRQLVVLMPN NPYDDSVLLP LVAQESDVPH ITVTTPVQSR QTFLARWAGD ASLEMPLPLV
     ALVGEFLGCD KADVQRAALL AGCTLLLQGH RGMQECYRAF CRRSANNRLL CMLRHHFLDF
     KDRLQTYHYA LSSGSSPSEA RHYLTQMSNC RLELKLLQLL CSGQHAPLQT YLISQPVSNI
     SVNIVEALVE LLSMAPKTAN EVTSDFMVQL LSTIAEALQG PCAANQDMFV AYNAADYLTL
     LLSEFDASPY GDAAFTAVEV VLPAVSWNEA ALGGEREGTS PAATLEERRR RCHSLLQTMA
     LSTLLAMIEG RDDSRLASKL VSTMDLSLLA KVMDRSAASY EARHGPIERK QYSGFSRGDI
     VGSVAALRRY FRDYLQNDNP TSREELQDEL AVAVSIYAFF RACHDMHFLT ATRPRCGSGG
     GVGAEDFAGA LDDLVDKKGQ GIRQVLRRSK YYRQVSTKLA KIEIVRDGRL ERVYFRALNS
     AVDNLFEFRR TALIQTAVRT SDNERIQHFF NETSDVIMEM SWYNSMRRFC AVYLLKFFLR
     EINALGLLIV FSINLVMVIG IRAPTSPYSS GTPEGIDRAL VGLGIVDMCV QGVLLTHALL
     GPAVVNYKIG WRTWYSRRQE ELTRMSDADI AVDRADALLR GKQCLVPTWY EWVLLSVYYA
     FWHADFLPHF FFCFVSVMGF AQHRIWYALQ MMQITIHSPV LASLFEALRA NLKLLVLTYA
     LLLTLVLVGA NISYYHLSQL FDPLGARLNG FNCYTLSQCF LVHVDTLRSG GGIGDVVNWP
     VFYSKDGYAY WVMFYRIAYY LVIGLVGANL FLGVIIDSLT QHRTHQQLIQ ADQEKKCFIC
     GIERNEFDIV RPGAYSTHVT EEHNMWQYIF FLHYLSTKDA NSHTGQEAYV QQLIAQQDLS
     FYPIGHSLTL RFRDRGAADA PMTEGGIPVG GEEDAEGGVP RVVAMAAEAG GGDGVDRKGA
     GGDGKNGGGA FDEATAHLIS SLVEAALKEG LEPLRRNIEK TNERIEEVRV NLQH
//
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