ID Q4QFM9_LEIMA Unreviewed; 4268 AA.
AC Q4QFM9;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE SubName: Full=Putative dynein heavy chain {ECO:0000313|EMBL:CAJ03160.1};
GN ORFNames=LMJF_14_1060 {ECO:0000313|EMBL:CAJ03160.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03160.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03160.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03160.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796410; CAJ03160.1; -; Genomic_DNA.
DR RefSeq; XP_001687705.1; XM_001687653.1.
DR STRING; 5664.Q4QFM9; -.
DR EnsemblProtists; CAJ03160; CAJ03160; LMJF_14_1060.
DR GeneID; 5650309; -.
DR KEGG; lma:LMJF_14_1060; -.
DR VEuPathDB; TriTrypDB:LmjF.14.1060; -.
DR VEuPathDB; TriTrypDB:LMJFC_140017900; -.
DR VEuPathDB; TriTrypDB:LMJLV39_140017700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_140017100; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_0_3_1; -.
DR InParanoid; Q4QFM9; -.
DR OMA; EKTMNAV; -.
DR Proteomes; UP000000542; Chromosome 14.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 691..1091
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1243..1584
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1907..1975
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2201..2289
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2362..2623
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2637..2967
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2994..3220
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3558..3671
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3732..3834
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3935..4264
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1604..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3828..3847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3867..3891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3920..3943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2638..2693
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2851..2934
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3867..3885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3929..3943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4268 AA; 473184 MW; C43F5DA402F57053 CRC64;
MMSTKVIQEL KELPLNTVED AQKFFSIVDD VKEQGVALPP ITHMFFARVD SGLHFEPYHI
RTICRDNRPM NYYVVTKGHV IHVDRRNGEY KVVATLEQWL LEAKCFNRIC KIAFFRNYIR
HKALLRLLES ARRTKLERIR AILSKRLLLA TPTFQKDLIA LRRKAFDFQW TPATEGFKKV
LSLQISGEKG NIAGFSTDEF VEMQDDYGKL LQRKFASLLL DILSVVVERV ENVTQLLSTM
RVIEKYPGAT GCVNKDVTAK ELHKRQMEQK RLVVDYEKLP SYIRLVHHFQ LESTFQQACS
TFFDLEGAVR RRAAILRWRF RVECIVEGRK ELSLFPSKEH VTKTAEAVMD KCIDLLSGAP
TCVGSEALKP FTTMIQTATV RSALLGDALI SVYKKEVLQF IEADYDEAKS KLSSYEPLVT
VSQFLAEWQD VSMNWDSTLS HENSLLVSIT ESEIRGYATR AYKAQSEIMK LSNRTYGTVV
VECDKTLQKL VAQLKGVLVD IEAALGQLIK LNFRYLKAEC DFWVGKLSLP DIALAQFINW
YLGLQDSGSI FDEFSNHVVD IQNLHRLLCE LREKSNAGVI NDEVDYSSVL RAPFQCAVTE
ARKYYLSNSS RIKEMLLAEH TRIIASVTST TKRLASEYSN ENANEIGAPV TQKLEDVRDE
LVQANSEARQ LDMYARVLEM QTFNWSEIAV AEDELQKYVE LWNVHKEATD LRHRLEAKTV
EEIDGQELKD TIVSLFQRAF KAQKNTPGCT ANYLVKSLAV EKANVPMYVE LCNPALKEAH
WLQLFQHTSI QLIPSAKRTL RSLEAAGLMT NEHSAAVREV VSSAVGVYEL EQQLKKLQDY
WANHLFVVVP YGGRSNAFVV DAVDATLEEL EEQQIVVQTC LTSKYLAPVQ TEMKEWEAKL
SLIHSVLMEW VGVQKAWMYL EFIFTSDDIK RQLPDESLLF SSADRFFGSL MKRCSEDPHM
APLCLEGNGD TLKKLQKCTY QLECIQKKID EYLETKRVAF PRFYFLSNDE LLSILSDSRN
PLAVQPHLQK CFDNIKALVF ADDKTIVAMR SSEGEEVLFT HPVKVIGNVE SWLNDVERAM
RATLFDCLAA CLRAYTTEHR TKWFFEHPAQ CVTTVDQIMW TREVEEVITA TGSGDSSAWS
SYQDRFGEQL LQTVELVKLS LTALQRTVVS NLIVVDVHCR DVCAELAADS ASAAPHPCSS
LLDFGWQKQL RFYYGPPTSA HGSGGVAEMA DCFVRHGAAE LPYGYEYLGN QPRLVITPLT
ERAFLTCTAA LHMQKGAAPQ GPAGTGKTES VKDLGKALAR TVVVFNCSDG LDYRMMSQMF
AGLAQAGAWA CFDEFNRIEL EVLSVVAQQM LDITTAITQR QTFMKFEGHH IKLHTNFGVF
ITMNPGYAGR TELPDNLKAL FRPVCMMIPN YALIAEIMFY AEGYGKAQSL AAKMIRLYSL
ASQQLSKQDH YDFGMRAVKS ILVLAGRLKR ADPDSDEELL LVRAIREANL PKFLVDDRHL
FMALLHDFFP TIVEVAPASV SEVILSEAKC FLTEELVHTS LSSPEAQMRL QPTEGLLFKT
QQLFDTLMTR HGLMLVGHTM TGKTTVRDTL ASVLTRLGRV LDTTPVPGAA GGDSGNGNPG
AKGGLAGTRR HTLAASMRAL DARCQSYFTT THATVCNPKA ISMTELYGDV NPLTREWQDG
VFSAIVRDLV KQSAAQHGRA ATRHWVIFDG PVDAVWVENL NTVLDDSKML CLVNGERIRI
PDTISLLFEV QDLRVASPAT VSRCGMVYVD EECVDGGWSP LLHSLSQAAA QELRAQWHHD
RFLQLCGSLV PPLLQVVREE CTEYIATCNA QLTLNLFYLM KAAVQHLQGV IDEDRQEQQK
QLRDDAAALV LDSGVSRPSI DSTFRRFSRR RSSRVTRTAV LVRGDAIFDA LFLQSCAWGL
GGNLTETTRA RFAAAMLPLV RKGALNFPAD AEAEGCGVFD YGVDYEIGDW RRWSEMVPEF
HYNASVPYFD LLVPTEQTAA LQYLLRSATT THHHMLLNGL TGTGKSSTVN SFLLQTLHTE
DAASSTAAFR FTLSAQTSAQ ALQNTIEMKL TRRKGDREFG APSGKTMMIA VIDDCNVPQL
EEYGAAPPVE LLRQMITQGG FYDRKRLFFK EVVQTMLIAC CGEPGGGKNE MTPRFTSKLL
CFCAPQLTET SMRSIFSAIL KGFFYARGFA TEVAALADAV VDSTLEAYRR IAVECLPTPD
KTHCTFNLRD VSKVFQGILQ IKPAHCASPQ ALIDLWSHEA SRVFHDRLID DTDRGWWWRC
CAEVIEKHFC GDVTAANADA ADTDAAQPVP SPLPAPDPAQ LATIFYGAWV NRDYQRIGQD
TSLQVVAQQH LAEYNTQSTT PMNLVFFDQA VQHLSRICRI VSQPRGHALL VGVGGSGRSS
LCRLAAFMMN MDVQTVHIAR NYGIEEFRDE VRKVLLDSGA RGKEVVFVIS DSQLVHSEML
EDINNLLNTG EVPGMMGLED METVVRCCRE ASLASGRPDT RASVYEYFVS QSRERFHLCL
CMSPMSGVFR DRLRMFPALV NCTTIDWFSE WPQEALRAVA QSTLSSAARD GAAGPGTDQL
SALMVLLQST VKDAAERLYA QHRRRTHVTP TSYLAVLTLY NTMGRRLRRD LQASANRYRN
GLKKLDTAKS TIAQLQQQIR EMQPGLAAAA KQVEEQKQTL AVEQLEANQM KEAQSKEEAT
ALQLMNEAES IRRECEEGLQ QALPALEAAK QALETLSAKD IQEIKTFTTP PSNVEKTMNA
VLVLLGEKDG WASAKACLGK LDFISRLTGY PRDSITPACI RKLAVFVQDP DFVPDIIEKT
SLPCRSMCMW VHAMYKYYFV AKEIAPKRAR LAGAEEKVEV ARKELQAKQV ALQKVLDHIS
DLQAAAAAAQ EKADHFQRQI ETAMARLVRA DQLISGLASE RVRWKEALAK LETQLGCVEG
TAALAAGCVG YLGPFPLDYR EVLVERWRSE CTALHIPFDA TYSLEGFETE ATVQQWALQS
LPRDTYSIQN ATILHRTTQC CYMIDPQGQA NAFVRKLERS RSSGAAGLLQ LKLNSPNFMR
QIENAVQKGQ AVLLEDVGET LDAALDPILL KQVRRVAGRD VVTLGDREVT YDDRFHLYIT
TKLANPVLTP ELQVKLTVID FTVTREGLEE QLLADIVGSE RASLQQRGDR CVISIAANRE
EIAALEAQVL QQLSDATGDV LDNAELIQAL QTSKVTSEKI GVELAAVEET NKTINATRDV
YRPLAVRGSL LYGAITQMAK VDPMYDYSLP FFKNLVVSVL ASTRRQRPQL QQPHRPSSIP
ASSMMLGNGS LHEREAQNCH VSLAPTDSSH GLPGASAEEE EEAAAAMSEA EVEARVVMLV
EEVTWMSYRV LCRGLFGPHK LLFSFVLATT LLRSTGQITK EEWELFLCGG AGRALPPAFA
AAGGEGSDGA TVQRPGYVSS GTWVDFGAIC GLEAFAEVYE SFIASLADTS DLGDADLSGD
RPLPWTAWFT ETYGAEVLTR LPASLAHLSL WHRVLAVKIL RPNKFHYMAA QLVADTLGQR
YTIAPPFDLE EAFLDSTKMT PIIFILSPGA DPTSLFLSFA EERGFSGRKH MLSLGQDQDV
RATQMIREGQ REGAWVYLQN CHVYASWMPQ LQALVESMNP SEIHADFRLW LTSNPSPSFP
PLVLQAGLKL TQEPPMGLRG KVLSTLRSTV VADVWAATAS AADVGNADSN DASVSASSPA
VLRGGHPSIE LQRLVWTLAF YHGTVMERRR YRPLGWNISY DWGMADFEAG LATLQTALDR
CKDGGAGLPT EELCYMLGTI DFGGRVTDEW DTLCLQVLTR RFFDTDAPGT TLQQKSPQDA
ITPPPFPKDG VSYAALLQLA EAAFTVGRES RKDGDGEDES GESPARFGLH DNATLSVEQQ
LSLGLVDALV LMNASGAVTG ATSAQRRSAS GDHGEEDAKA SGDEAMENPV AAVARNLLAQ
LPPLLPRQEA VLGSMTSPNH STTTTTAVSA VADPAPLQTL LSHETDLYNC LLSTMQSSLA
ELIRALKGEV VVTSRLELMM QRLAFNQVPE VWAQVGYLTL KPLGSFMEDL LRRVHFMRRW
GEAGPPPSFW LSGVFFPQGF VTALLQARSR ALQVPIDSLQ LRFRALAPSE AAEVSALTAS
HEAGTGSKAP TLVGAYVNGL YLEGCGWDAA RGGLVEAAPG ALTVELPIIH FEPVMGSESV
AKGPSASAAE AAAAYVCPLY KVRTRAGTLS TTGVSTNYVT SLTLPSLDGV PGDHWTLRGV
AALCALDN
//