ID Q4QHZ0_LEIMA Unreviewed; 852 AA.
AC Q4QHZ0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=LMJF_09_0350 {ECO:0000313|EMBL:CAJ02451.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02451.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02451.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02451.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796405; CAJ02451.1; -; Genomic_DNA.
DR RefSeq; XP_001681208.1; XM_001681156.1.
DR AlphaFoldDB; Q4QHZ0; -.
DR STRING; 5664.Q4QHZ0; -.
DR EnsemblProtists; CAJ02451; CAJ02451; LMJF_09_0350.
DR GeneID; 5649463; -.
DR KEGG; lma:LMJF_09_0350; -.
DR VEuPathDB; TriTrypDB:LmjF.09.0350; -.
DR VEuPathDB; TriTrypDB:LMJFC_090010000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_090009100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_090008700; -.
DR eggNOG; ENOG502RSIV; Eukaryota.
DR HOGENOM; CLU_335085_0_0_1; -.
DR InParanoid; Q4QHZ0; -.
DR OMA; HCYHQNC; -.
DR Proteomes; UP000000542; Chromosome 9.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 790..842
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 86426 MW; 3ADECFE330803213 CRC64;
MKSLAREFRE LEATSQLPPS TPQQCVAPST VLLPAAVGTV PPQLSPFVAN TAAALSPQAS
RQMCMAPLLG LSSFPRSPLH NGSTTLQTTN DGCPDTRADR VGSRSCSVID SFGRSSPPTP
SVALRIGDGS RNSGPSGTAH AHAAPAARSA DEDSALDPLT SSSSPTATAC LSQGTPENSL
MMNTTSATAT ANRTGSGSRR SSRSGARLDR DRRCSTTPPY TEVHAHHQQP RLACDTSLAW
VLTPACDPSG LSTPGVGGAA SQAGSVHHYA PPFPSFAKSV CALHPLTDVM EPTTAAPAAA
PSIPPRAASR EQVSSRPPSM AAKQETPHQA PGQPQGPLST TTVTASPMSP TTAPVQLSLQ
EKLLISAPLT PRSGRGTPSS TLHVAPSPPR RRCSSATNPS ISTVGVKPDS GKSRRGGSAT
TAAAATAMAA AFTSSQLAPS PAAPATATLP SPPPCMRLRS TGDGNSARSN PNNMSVCSIP
SAVAVVPIEV QPAILSASPS FFATSPCQSP ARAAVSASDS GAFIYGVAAA SAVPYTPSAP
KMAAIEQPGQ ASADPRASAT PPLQRNPASP TAQPVQNPAY WSVPCTPAVP MTVFLAAPEM
SWHSLTGGVT TPPASSIGVA IPDPCSQNFF VGCSVRGTGT SILDGCSSTA SIATPLATSP
ASSAALDPQR TSGNRGATRT SAGQTYRNVL VYGGGGTSGQ GGGCATAVTA SGSSHGLGLP
LYSSQPQLLC TPVPLEDTES VCAICLEGRA SRTRTTETRE TTALPSTPLQ PPHAAGEGAR
QASDSAAAGM CDTTPADEGA ERGAVRGVKP GSCLLSLPCG HCYHQNCLQR WLMESQSCPT
CRRDLTRDAT IS
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