ID Q4QIN4_LEIMA Unreviewed; 1196 AA.
AC Q4QIN4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop domain-containing protein {ECO:0000259|Pfam:PF16575};
GN ORFNames=LMJF_07_0580 {ECO:0000313|EMBL:CAJ07019.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ07019.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ07019.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Friedlin;
RA Peacock C.S, Murphy L., Ivens A.C, Berriman M., Blackwell J., Smith D.,
RA Collins M., Fosker N., Harris D., Oliver K., O'Neil S., Saunders D.,
RA Seeger K., Warren T., Rajandream M., and Barrell B.G.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAJ07019.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00011003}.
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DR EMBL; FR796403; CAJ07019.1; -; Genomic_DNA.
DR RefSeq; XP_001680964.1; XM_001680912.1.
DR AlphaFoldDB; Q4QIN4; -.
DR STRING; 5664.Q4QIN4; -.
DR EnsemblProtists; CAJ07019; CAJ07019; LMJF_07_0580.
DR GeneID; 5649216; -.
DR KEGG; lma:LMJF_07_0580; -.
DR VEuPathDB; TriTrypDB:LmjF.07.0580; -.
DR VEuPathDB; TriTrypDB:LMJFC_070012300; -.
DR VEuPathDB; TriTrypDB:LMJLV39_070012000; -.
DR VEuPathDB; TriTrypDB:LMJSD75_070012200; -.
DR eggNOG; KOG2750; Eukaryota.
DR HOGENOM; CLU_271319_0_0_1; -.
DR InParanoid; Q4QIN4; -.
DR OMA; WDWVEAT; -.
DR Proteomes; UP000000542; Chromosome 7.
DR GO; GO:0005730; C:nucleolus; ISO:GeneDB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IBA:GO_Central.
DR GO; GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 684..821
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..318
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 127395 MW; 5D34D5BBA3E89CEA CRC64;
MEASPASSPR SPALTTKTSQ LPFTAPEALP TAVEEVSEAV VSAAVAAHQT ASSSYAQDDG
QETLLLPRQQ KPVIFSRQWR RQLFAGTASS SLPLESGKPI TGSTVEDVLR GHVQSIGRRA
RGDVRESDSD SVADEEGDDD EEDASPFGKA SVIKFSRTED SGGVPGRLAA VPSSGDSGDG
EDRLSAESAF MMQATAGRAV HGRRNGAALQ SSGALTRRQR HQLRQQAQEA REHHRVRRHM
AGFDPDFLSR QESRMQVHRE RDSNEEGEDE ESGAHSSEGE TDYSASSTAE SEALSSVSAE
GDDDEGEEAE EDGDVDGDLL DPSASAPHGD LSAAGGGGFG AAERTEHERQ GRAHDKSGTA
APPAQVDEPG DSGSNTSPAA VRSQFFQSFF FACHEDRMCR SGCHHTLVGL RDSVTIKGPC
GIIGFGLGEV SVNGFYLGRK QLTLWHEEHR AVLMPMKRLK TRHAQDMELP QWHRVPAPPW
PSRSFSTAAA AGESTSMDAG DALGQPLNPL YYRGVCDASR SRTSATVNGT PAAPAAAAAE
GPDEEEAFLQ SLQWSCESVF GAVDWDWVEA TVQSWRNLFS NQLPPIFLIL QPSSSMRRRG
GEGPTRRFYL TRKRGRQDGA AGGQSKVSKK GGASQDADAA PSSTYMDIPS FVAHRSEPSV
DLALVPSIVP SIAAQGCGSV MVLGSANIGK STLCRYLANV LLSQHGLCYW LDLDVAQPEF
GVPGQLTLSI VRRPLLRAHD ASCAQIVAAF FIGASTPAPC PLTAANALAA VCAQARAVSR
EHPVVVNTHG WVLQTGRRVS VEALRRLRPR QVIHLHKARE ELWVQDTAAL LDPRNGLNAE
VVQRRFLVRY SSASSPAAAA AGENSGGPAA GSKKNRIKGA PLSSATPSAA LLCRLPYPHA
REDAVQPPAP SDRESPVSSP TTTSSHRWRG QVHSVRVERE ETYSSIARIK ATKGSRGRQQ
RWETYFSALL RHYAGRTAAG AKAASDHPNA EEPETTLLEA PLSALHSIVL AERDEKLGDV
CLVEPTLPSS SSAEVKSRAT AAVAGAERRR SRQTHAELAA ALEHAVVAVL FHAQPSAVAA
HGQPNGGERC GVVRSLASLQ NGFPVSCYGV VESGERELLH GVEAAQREKD ASSSWGSSAS
AGWIRIRVPL RPSVVAAMLS NPESGPAAAA AKRCTCVSIA YSAALRSETA FVDAWR
//
