ID Q4QJA1_LEIMA Unreviewed; 615 AA.
AC Q4QJA1;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Methyltransferase-like protein {ECO:0000313|EMBL:CAJ02021.1};
GN ORFNames=LMJF_05_1010 {ECO:0000313|EMBL:CAJ02021.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02021.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02021.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02021.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796401; CAJ02021.1; -; Genomic_DNA.
DR RefSeq; XP_001687578.1; XM_001687526.1.
DR AlphaFoldDB; Q4QJA1; -.
DR STRING; 5664.Q4QJA1; -.
DR EnsemblProtists; CAJ02021; CAJ02021; LMJF_05_1010.
DR GeneID; 5648966; -.
DR KEGG; lma:LMJF_05_1010; -.
DR VEuPathDB; TriTrypDB:LmjF.05.1010; -.
DR VEuPathDB; TriTrypDB:LMJFC_050016500; -.
DR VEuPathDB; TriTrypDB:LMJLV39_050015200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_050015600; -.
DR eggNOG; KOG2671; Eukaryota.
DR HOGENOM; CLU_444442_0_0_1; -.
DR InParanoid; Q4QJA1; -.
DR OMA; ESCAAKK; -.
DR Proteomes; UP000000542; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CAJ02021.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 224..383
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT REGION 531..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 67244 MW; A1BA4850E051ED06 CRC64;
MKYVAVFASS ASLADFRLPE FQFVAATLGV PITFLDDKIP WVAGGGDTFW FSVFESPASR
SELKALAERC ALLRGVYTLF ETAPTLEDLY VCLEERHGSA PGSAGPSLAS SPTTAATAFV
GEDETTHLTS STYSYQVETI GKKYSADAKR AVAEAVLKRV PRAGEVEWRQ PGRAYYVFLQ
HAVENPPPGA QGWVSNGPLL RVFHCRLCVE SSRSALLATY DLRKRPYIGT TSMPPEESLM
MVNMSGVCRG HYVYDPFCGT GSLLIAAAHY GARTFGSDAD GRAMRAGTEK GKTSPQMQQQ
RRLALAAYTE EQLCVLTEEE RVLPSMITNF KLYRLPPPDR ARMNFSAWPR TWHACAPHLG
SGGIFDSIIT DPPYGLREPR KRMETTAATI PTAAAAAAST EAGSDNAAKQ QAVTFSAYPT
HEVLLDLVMF AATYLVVGGH LTFWHPTTDH YTNDELPSHP SLSIVCDIMQ RVSLKVVRRL
IVLRKVMPVP KPPPSRESCA AKKSPDDLRV LMDATEIPDN ADYMHYRAKR ERKRQAAHKY
KASAGASSSP STPAAGVDVG SGSDGGNRRG RKHSRLDGQE KIVANRQRNI ELRAAKQAAS
HLANTAHKTV DHSRP
//
