ID Q4QPJ4_HAEI8 Unreviewed; 423 AA.
AC Q4QPJ4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=TRAP transporter large permease protein {ECO:0000256|RuleBase:RU369079};
GN OrderedLocusNames=NTHI0060 {ECO:0000313|EMBL:AAX87053.1};
OS Haemophilus influenzae (strain 86-028NP).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=281310 {ECO:0000313|EMBL:AAX87053.1, ECO:0000313|Proteomes:UP000002525};
RN [1] {ECO:0000313|EMBL:AAX87053.1, ECO:0000313|Proteomes:UP000002525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=86-028NP {ECO:0000313|EMBL:AAX87053.1,
RC ECO:0000313|Proteomes:UP000002525};
RX PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA Munson R.S.Jr.;
RT "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL J. Bacteriol. 187:4627-4636(2005).
CC -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC transport system. {ECO:0000256|RuleBase:RU369079}.
CC -!- SUBUNIT: The complex comprises the extracytoplasmic solute receptor
CC protein and the two transmembrane proteins.
CC {ECO:0000256|RuleBase:RU369079}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU369079}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU369079}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TRAP transporter large permease family.
CC {ECO:0000256|RuleBase:RU369079}.
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DR EMBL; CP000057; AAX87053.1; -; Genomic_DNA.
DR RefSeq; WP_005668000.1; NC_007146.2.
DR AlphaFoldDB; Q4QPJ4; -.
DR GeneID; 72526094; -.
DR KEGG; hit:NTHI0060; -.
DR HOGENOM; CLU_019824_4_1_6; -.
DR Proteomes; UP000002525; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR010656; DctM.
DR InterPro; IPR004681; TRAP_DctM.
DR NCBIfam; TIGR00786; dctM; 1.
DR PANTHER; PTHR33362:SF4; 2,3-DIKETO-L-GULONATE TRAP TRANSPORTER LARGE PERMEASE PROTEIN YIAN; 1.
DR PANTHER; PTHR33362; SIALIC ACID TRAP TRANSPORTER PERMEASE PROTEIN SIAT-RELATED; 1.
DR Pfam; PF06808; DctM; 1.
DR PIRSF; PIRSF006066; HI0050; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU369079};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369079};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369079};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369079}; Transport {ECO:0000256|RuleBase:RU369079}.
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 103..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 169..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 239..257
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 269..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 312..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 352..378
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT TRANSMEM 398..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369079"
FT DOMAIN 6..414
FT /note="TRAP C4-dicarboxylate transport system permease DctM
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF06808"
SQ SEQUENCE 423 AA; 45396 MW; 44F31D7CCF58E5D5 CRC64;
MLLLFLCSLF LLLFLGVPVA LSMLLSASIM LYHLDMFDTQ LITENFVMGT NNFPLMAIPF
FMLTGEIMKH GGISERIINF ATSMVGHIKG GLGYVAIISG LIFAGLSGSA VADTAALGAI
LIPMMISKKY DGARSTGLIC AAGIISVVIP PSIPMIIYGI TAGASITKLF MGGTVPGLLM
VVGLWVTWKI LYRNNDTSLE RKQTGKERWV AFKKAFWPLL LPIIIIVGLR GGIFTPTEAG
VVAAIYAGIV SIAYKGLTFS KLKDVFIGTI KTTSMVMFVA ASAMISAFAI TVAQIPTELV
QTIKGLTDSP TILMFIIMLF LLLVGCVMDL IPAVLIFVPV LLPVLRAYNI DIAYFGIMMV
INLSIGLITP PVGTVLYVGS GISKLGIGAL SKGIAPFLFV YAIIMMLIVF FPEIVIVPMN
WLS
//
