ID Q4QTL5_WOLPI Unreviewed; 320 AA.
AC Q4QTL5;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Serine hydroxymethyltransferase {ECO:0000313|EMBL:AAY81978.1};
DE Flags: Fragment;
GN Name=glyA {ECO:0000313|EMBL:AAY81978.1};
OS Wolbachia pipientis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Wolbachieae; Wolbachia.
OX NCBI_TaxID=955 {ECO:0000313|EMBL:AAY81978.1};
RN [1] {ECO:0000313|EMBL:AAY81978.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WRi {ECO:0000313|EMBL:AAY81978.1};
RX PubMed=16269725; DOI=10.1128/AEM.71.11.6910-6917.2005;
RA Mavingui P., Van V.T., Labeyrie E., Rances E., Vavre F., Simonet P.;
RT "Efficient procedure for purification of obligate intracellular Wolbachia
RT pipientis and representative amplification of its genome by multiple-
RT displacement amplification.";
RL Appl. Environ. Microbiol. 71:6910-6917(2005).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; AY833067; AAY81978.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4QTL5; -.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR CDD; cd00378; SHMT; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00051; SHMT; 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR Pfam; PF00464; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00096; SHMT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000313|EMBL:AAY81978.1};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAY81978.1}.
FT DOMAIN 1..320
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAY81978.1"
FT NON_TER 320
FT /evidence="ECO:0000313|EMBL:AAY81978.1"
SQ SEQUENCE 320 AA; 34573 MW; 66FA812C2689AA32 CRC64;
KAVMEAQGSF LTNKYAEGYP GKRYYCGCEH VDKIESLAIE RLCKLFGVKF ANVQPHSGSQ
ANQAVFASLL TPGDTILGLS LSCGGHLTHG AAPSLSGKWF KSIQYTVNKD TYLLDMDEIE
KLALEHKPKL IIAGASAYPR KMDFKRFREI ADKVGAYLLA DIAHYAGLIA AGEYPSPAEY
AHVMTSTTHK TLRGPRGGIV MTNDEILHKK IQSAVFPGLQ GGPLMHVIAA KAVAFKEALA
PGFKTYSKKV VENAKVLAQE LQKHGLDIIT GGTDSHIVLV DLRSQKLTGK DVVDSLERAG
ITCNKNSVPF DTAKPTITSG
//
