ID Q4QVS6_9HIV1 Unreviewed; 342 AA.
AC Q4QVS6;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAV66791.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAV66791.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAV66791.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HS507 {ECO:0000313|EMBL:AAV66791.1};
RX PubMed=15956571; DOI=10.1128/JVI.79.13.8249-8261.2005;
RA Gerhardt M., Mloka D., Tovanabutra S., Sanders-Buell E., Hoffmann O.,
RA Maboko L., Mmbando D., Birx D.L., McCutchan F.E., Hoelscher M.;
RT "In-depth, longitudinal analysis of viral quasispecies from an individual
RT triply infected with late-stage human immunodeficiency virus type 1, using
RT a multiple PCR primer approach.";
RL J. Virol. 79:8249-8261(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY775621; AAV66791.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AAV66791.1};
KW Virion {ECO:0000313|EMBL:AAV66791.1}.
FT TRANSMEM 157..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..198
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 195..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAV66791.1"
SQ SEQUENCE 342 AA; 39423 MW; 5BD809B878348EE4 CRC64;
FLGAAGSTMG AASMTLTVQA RQLLSGIVQQ QSNLLRAIEA QQHMLKLTVW GIKQLQARVL
AVERYLRDQQ LLGIWGCSGK LICTTNVPWN YSWSNKSHDE IWGNMTWMQW DKEISNYTEI
IYSLIEESQN QQEKNEQDLL ALDKWASLWT WFDITKWLWY IKIFIMIVGG LIGLRIVFAV
LSVINRVRQG YSPLSFQTHT PNPRGLDRPG RIEEEGGEQG RDRSIRLVNG FLALAWDDLR
SLCLFSYHRL RDFILIVVRT VELLGHSSLK GLRLGWEGLK YLWNLLAYWS RELKISAINL
IDTIAIVVAG WTDRVIEIGQ RVGRAILNIP RRIRQGFERA LL
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