GenomeNet

Database: UniProt
Entry: Q4R6C2
LinkDB: Q4R6C2
Original site: Q4R6C2 
ID   ZN383_MACFA             Reviewed;         475 AA.
AC   Q4R6C2;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-APR-2014, entry version 51.
DE   RecName: Full=Zinc finger protein 383;
GN   Name=ZNF383; ORFNames=QtsA-18358;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcriptional repressor, suppressing
CC       transcriptional activities mediated by MAPK signaling pathways (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By
CC       similarity). Note=Shuttling between the nucleus and cytoplasm may
CC       occur under different stimulation and growth conditions (By
CC       similarity).
CC   -!- DOMAIN: The KRAB domain is responsible for the transcriptional
CC       repressor activity (By similarity).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 11 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AB169263; BAE01353.1; -; mRNA.
DR   RefSeq; NP_001271075.1; NM_001284146.1.
DR   RefSeq; XP_005589076.1; XM_005589019.1.
DR   RefSeq; XP_005589078.1; XM_005589021.1.
DR   RefSeq; XP_005589079.1; XM_005589022.1.
DR   RefSeq; XP_005589080.1; XM_005589023.1.
DR   RefSeq; XP_005589081.1; XM_005589024.1.
DR   RefSeq; XP_005589082.1; XM_005589025.1.
DR   RefSeq; XP_005589083.1; XM_005589026.1.
DR   RefSeq; XP_005589084.1; XM_005589027.1.
DR   RefSeq; XP_005589085.1; XM_005589028.1.
DR   UniGene; Mfa.3511; -.
DR   ProteinModelPortal; Q4R6C2; -.
DR   SMR; Q4R6C2; 195-451.
DR   GeneID; 101865100; -.
DR   KEGG; mcf:101865100; -.
DR   CTD; 163087; -.
DR   HOVERGEN; HBG018163; -.
DR   KO; K09228; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 11.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    475       Zinc finger protein 383.
FT                                /FTId=PRO_0000047551.
FT   DOMAIN        6     77       KRAB.
FT   ZN_FING     170    192       C2H2-type 1.
FT   ZN_FING     198    220       C2H2-type 2.
FT   ZN_FING     226    248       C2H2-type 3.
FT   ZN_FING     254    276       C2H2-type 4.
FT   ZN_FING     282    304       C2H2-type 5.
FT   ZN_FING     310    332       C2H2-type 6.
FT   ZN_FING     338    360       C2H2-type 7.
FT   ZN_FING     366    388       C2H2-type 8.
FT   ZN_FING     394    416       C2H2-type 9.
FT   ZN_FING     422    444       C2H2-type 10.
FT   ZN_FING     450    472       C2H2-type 11.
SQ   SEQUENCE   475 AA;  54626 MW;  10416E124D764EF5 CRC64;
     MAEGSVMFSD VSIDFSQEEW DCLDPVQRDL YRDVMLENYS NLVSMGLYTP KPQVISLLEQ
     GKEPWMVGRE LTRGLCSDLE SMCETKLLSL KKEVYEIELC QREIMGLTKH GLEYSSFGDV
     LEYRSRLAKQ LGYPNGHFSQ EIFTPEYMPT FIQQTFLTLQ QIMNNEDRPF ECKKCGKAFS
     QNSQFIQHQR IHIGEKSYEC KECGKFFSCG SHVTRHLKIH TGEKPFECKE CGKAFSCSSY
     LSQHQRIHTG KKPYECKECG KAFSYCSNLI DHQRIHTGEK PYACKVCGKA FTKSSQLFQH
     VRIHTGEKPY ECKECGKAFT QSSKLVQHQR IHTGEKPYEC KECGKAFSSG SALTNHQRIH
     TGEKPYDCKE CGKAFTQSSQ LRQHQRIHAG EKPFECLECG KAFTQNSQLF QHQRIHTDEK
     PYECNECGKA FNKCSNLTRH LRIHTGEKPY NCKECGKAFS SGSDLIRHQG IHTNE
//
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