ID Q4RVF8_TETNG Unreviewed; 842 AA.
AC Q4RVF8;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
DE Flags: Fragment;
GN ORFNames=GSTENG00028355001 {ECO:0000313|EMBL:CAG07624.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG07624.1};
RN [1] {ECO:0000313|EMBL:CAG07624.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG07624.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG07624.1}.
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DR EMBL; CAAE01014992; CAG07624.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4RVF8; -.
DR ESTHER; tetng-q4rvf8; DPP4N_Peptidase_S9.
DR MEROPS; S09.973; -.
DR KEGG; tng:GSTEN00028355G001; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..520
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 628..829
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 842
FT /evidence="ECO:0000313|EMBL:CAG07624.1"
SQ SEQUENCE 842 AA; 95934 MW; 93D3B1BD522197FB CRC64;
MTSAKDANEP LKAAQQPQEQ DLVGSAPPQR NWKGIAIALL VILIICSLIV TSVIVLTPRE
DNSLALMKKV TVEDVFGPDL HIHDPEARWL SDNELLYRDR DGDVVKFNVD TERRDVIVPN
QWFKRCRATK YQVSPDLQHV LFAFEVKPIY QHSFVAKYII YSLQTQETWV LNPPEVQEAA
LQFAGWGPRG QQLIFIFENN IYYRATVESR VIRLVSTGKE GVVFNGLADW LYEEEVLQSH
VAHWWSPDGL RLAYMTINDT LVPKMEIPFF TGMPYPTHLE YHYPKAKTNP EVQLSVASLN
GPLHTVVMKK PDDPRIGREY YITMVNWATS TKLAVTWLNR GQNNSILTLC EATTGICVKK
HEDESESWLH RQNEAPLFSK DGHRFFFTRA IPQGGRGKFF HISMSTFLVK TLQRYPAFPA
FPGVSPVVSF QPNTSTDILQ SLTSGDWDVT KILAYDHQKN LIYFLSTEDD PKRRHLYSAD
TIAPFNRCCL SCEFNCSYVD VSFSHNMRYF LLSCRGPQVP SVAVYSTQSR LKVFDVETNK
RVGDAYGSMQ MPKVENKIIV IDDYSTWGCA RSRRQTSLLS AHRPVPSVAA LTMQILKPAG
FVDTAHYPLL LLVDGTPGGQ MVSEQFRVDW ATVLVSSFST IVIHFDGHGS GFQGTNFLHK
VRRKLGKLEE RDQLEALRFI SKEPYIDKTR MGVYGRAYGG YLATMLLSSE EFTQLKCGAA
VSPITDFEIY ASAFSERYLG SKTDSRAYTL ANLAHRAHQL VQKQYLIIHP TADEKVHFQH
TAKFINHLIS EKTNYTLQIY PDEGHFLHSD GTQQHLSQSL VNFFEECFRK PEKGEDDDEE
DE
//
