ID Q4RW99_TETNG Unreviewed; 1019 AA.
AC Q4RW99;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=(spotted green pufferfish) hypothetical protein {ECO:0000313|EMBL:CAG07333.1};
DE Flags: Fragment;
GN ORFNames=GSTENG00027960001 {ECO:0000313|EMBL:CAG07333.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG07333.1};
RN [1] {ECO:0000313|EMBL:CAG07333.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG07333.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG07333.1}.
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DR EMBL; CAAE01014991; CAG07333.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4RW99; -.
DR KEGG; tng:GSTEN00027960G001; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 860..1006
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG07333.1"
FT NON_TER 1019
FT /evidence="ECO:0000313|EMBL:CAG07333.1"
SQ SEQUENCE 1019 AA; 116850 MW; 9964A922DE18A7A9 CRC64;
PIFLPCDTDV NTTRVDCSDR HITHVPIIRS NTVTSLRLSR TKIFQVGPDN LSHMPNLRVF
IMADNCQPSG MKATLHACKV EINHFAFSRS LQLQVLNLSG NSLTSLPWLP EKLKVLNLQR
NRLFNIVEPL KTPYLKELNL AKNCFHANPC LQSLNISDSV FSELSQLKTL SLAQNNLTSV
PKALPSSLEH LDLSENTITE VLEGTFADFI HLNHLNLEWN CQRCDHAAQP CFPCPKNQPL
QLYSKSFYTN KSSLIFLSLR GNSLRTFPKG LFQPLKKLAY LDISDNFLSD AIQKGSFFAE
LTSLSWISLI YNYEPLKTLP RLSLSPHIGT ISGLQHLLLS GNFFHSFSPQ SFEVLYKLQK
LTRLELRMNF INTFDLKALK RVPSLTSINL SQNILSVFSD CPISSAEREI CHNQSTCNLG
SSNPSLVRKG QNVTFERDFL DQFDRLEMSS PQSSLLWKKF CQKKVTFDLS QNNIISVNRK
VLAGMEHVAC LDLSFNYMSQ TLRSGMFDGM KYLVFLNLSY NRLDLYYDEA FSELKDTLKL
LDLSNNDYHF KMKGMGHRLT FIKNLVNLEV LSLANNAIAA RIDQRLVSDS LKQLYFSGND
LNLMWSSENN QYLNFFQNLT NLTYLDISDN KIRLVSPKVL CNLPTSLQNL SLSNNRLTYF
PWENISALTN LHHLDLSQNF ITFLPHIVIQ APASFLLLDL SHNRINYLPQ SFFRAMNSLR
RLYLSHNQLK QFDHQLALFK STSALQMLSL HANPFNCDCS ASRFVDFLRN TLVDIPHLTT
EVNCEYPESQ RGKAMLSMDQ PSCQDMYGSL ASVICSFLVV AFTLLPLLKH LYGWDLWYSL
QVFWAECKGY SQLSGRDVKY NYDAFVVFDT SKLDVRDWVY NELLVHLENS AHRRFCLCLE
ERDWVPGLSC IENLHNAVSS SMKTVFVLSN DTLEPMSGVI RQAFFMVQQR LLDEKVDAAV
LVLLDETFPK VKYLQLRKRL CRKSVLSWPK NPKAQPLFWN QVRMALSSDN LSFYDNNMS
//
