ID Q4RXK3_TETNG Unreviewed; 2055 AA.
AC Q4RXK3;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE SubName: Full=(spotted green pufferfish) hypothetical protein {ECO:0000313|EMBL:CAG06879.1};
DE Flags: Fragment;
GN ORFNames=GSTENG00027380001 {ECO:0000313|EMBL:CAG06879.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG06879.1};
RN [1] {ECO:0000313|EMBL:CAG06879.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG06879.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG06879.1}.
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DR EMBL; CAAE01014979; CAG06879.1; -; Genomic_DNA.
DR KEGG; tng:GSTEN00027380G001; -.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF11; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 2.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 79..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 993..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1505..1539
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 258..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1642..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1727..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1665
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1727..1755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1775..1808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1865..1889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 513
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 864
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG06879.1"
FT NON_TER 2055
FT /evidence="ECO:0000313|EMBL:CAG06879.1"
SQ SEQUENCE 2055 AA; 233238 MW; 729FF3A9E7D6CA65 CRC64;
DFSFSCDRLF SVVLEFLTKE EKGNGESSQP SMHGHGGKPG GFDVKALRAF RVLRPLRLVS
GVPSLQVVLN SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FIGKMHATCY IPGSDSIAEE
EPAPCAISGH GRQCPINGTE CREGWQGPNG GITNFDNFLF AMLTVFQCIT MEGWTDVLYW
MNDAMGFELP WVYFVSLVIF GSFFVLNLVL GVLSGEFSKE REKAKARGDF QKLREKQQLE
EDLKGYLDWI TQAEDIDPDN EDEADEEAKR NPSVPASETE SVNTENQNGE DEKTTCCGPL
CQKISKSKFS RRWRRWNRFC RRKCRLAVKS VPFYWLVIIL VFLNTLTISS EHYNQPLWLT
EVQDVANKVL LALFTCEMLM KMYSLGLEAY FVSLFNRFDC FVVCGGITET ILVELEIMSP
LGISVFRCVR LLRIFKVTRH WQSLSNLVAS LLNSMKSIAS LLLLLFLFII IFSLLGMQVF
GGKFNFDETQ TKRSTFDNFP QALLTVFQIL TGEDWNAVMY DGIMAYGGPS SSGMIVCFYF
IILFICGNYI LLNVFLAIAV DNLADAESLN KDEDKKGGQR RQGTPSQRGA AETAVLAPQL
PDRLCLTSGG RRGQRRHRGG GGGSRGSVGA SACHLRSGEE GEDHPHSRGK RLLHLQQHQP
ILGYFDYAFT AIFTVEIVLK VLGYADYVFT SMFTFEIILK MTTYGAFLHK GAFCRNYFNL
LDLLVVGVSL VSFGIQSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC VFVAIRTIGN
IMIVTTLLQF MFACIGVQLF KGKFYRCTDE AKSSPEECKG TYILYKDGDV NQPTIHKRVW
HNSDFNFDNV LMAMMALFTV STFEGWPALL YKAIDSNREN LGPIYNYRVE ISIFFIIYII
IIAFFMMNIF VGFVIVTFQE QGEKEYKNCE LDKNQVSVAA GLQKVEYCCA GSGCGRSQRQ
CVEYALKARP LRRYIPKNPY QYKFWYVVNS TGFEYIMFVL IMLNTLCLAV QHYGQSALFN
YVMDILNMVF TAVFTVEMVL KLIAFKPRGY FGDAWNVFDA LVVIGSIVDI VLSEIDLMPV
VDPRTPHFSH THLVLPSFHV LHRWRSVTRS IPHRTRRTAL ALSITFFRLF RVMRLVKLLS
RGDGHPYFTL DVHQIVHKGE ERCSRQALPY VALLIAMLFF IYAVIGMQVW HLTSQNVALE
WLLPQLNVFV RSRRSRCSGR SLWWTAHTLT GTTTSRPSPR PCCSSSGVQE SGSRARVREG
QVCEAQGCVC LVCVSQMCHW RGVAGDHVGL YAWKTVRPRV RLQPRRGDDL RQRLRHRLLH
HLLHALRVPD HQLVCCRHHG QLRLPNTRLV HSGSTPPRRI QEDLVRVRPR GKVRSCDLKT
RNPSGSPAVT CTLTTLLVCF FSNLGAELNI WTWSRSFVAS SLRSASGSCV LTGWPARLVA
MNMPLNSDGT VMFNATLFAL VRTALKIKTE GNLEQANEEL RAVIKKIWKR TSMKLLDQVV
PPAGDDEVTV GKFYATFLIQ DYFRKFKKRK EEGLVGAHPS QNSTAMALQA GLRTLHDIGP
EIRRAISCDL QDDELVDFIP EEDEEIYRRN GGLFANHLMN GGHRRSNGHQ TNATQRPLQV
QPPPHYAHME QPVGRLSRAN AMSHHNHHHH HHHHHHHRRH HNSYGKSPKS TNINLNNANV
STLPNGGHHR YYEHAPPNGY PGLRNAYYNK PRTPQTQRRR YYETYVRSHG ADGHHPTIRR
EEEFDEDRLS GEYYSGEEFY EDDSMLSGDR YQTSDTEYET PKGYHHPDAY YDDDEQPLYH
DSRRSPKRRL LPATPQGNRR PSFNFECLRR QSSQDELPHP RTALPLHLMQ HQVMAVAGLD
SSRAHRLSPT RSTRSWATPP ATPASKDQSP YYTPLIRVEQ PHRESGVSVR KCSWYTDDPD
FPHRTYSPVH LQVPPEYHSQ FHQKRGSATS LVEAVLISEG LGRYAKDPNF VAATKHEIAD
ACEMTIDEME SAASHLLNGG MTPGVNGVSV FPILTPRDFD LQETAASYSD EEPEAEPRAP
YEEDLADEMI CITTL
//
