ID Q4RYN3_TETNG Unreviewed; 1669 AA.
AC Q4RYN3;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE Flags: Fragment;
GN ORFNames=GSTENG00026865001 {ECO:0000313|EMBL:CAG06499.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG06499.1};
RN [1] {ECO:0000313|EMBL:CAG06499.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG06499.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; CAAE01014974; CAG06499.1; -; Genomic_DNA.
DR MEROPS; C19.009; -.
DR KEGG; tng:GSTEN00026865G001; -.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028135; Ub_USP-typ.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF13202; EF-hand_5; 2.
DR Pfam; PF14836; Ubiquitin_3; 1.
DR Pfam; PF00443; UCH; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 230..265
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 266..301
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 371..601
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 766..1632
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 438..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG06499.1"
SQ SEQUENCE 1669 AA; 186335 MW; 14E93DA8DA7CF25F CRC64;
NEGSMGAKES RIGFLSYDEA VKRVTDVELK RLKDAFKRTS GLTCYMTQQC FFREVLGDGV
PPKVAEVIYT SFGGSSKGLH FNNLIVGLVL LTRGRDEEKS KCTLFASDLG GYAAREDIEA
VLRILDGETP ASLQKCFLES DKVSYERFRA WLFLNKDAFT LSRWLLSGGV CVTLTDDSDT
PTFYQTLAGV THLEESDIID LEKRYWLLKA QSRTGRFDLE TFIPLVSPPI HASLSEGLFN
AFDENRDNHI DFKEISCGLS ACCRGPIAER QKFCFKVFDV DHDGVLSRDE LHEMVVALLE
VWKDNRTDTL PELTSTVSDI VEGILKMHDT TKLGHLTLED YQIWSVSSAL ANEFLNLLFQ
VCHIVLGLRP GTPEEEGQII RGWLERESRH GLQQGQNWFL ISMLWWQQWK DYVKYEHKGI
VSEQPTLLSA LRNSVSASTV EPMPPDRLGG LGTFSSVSPT EERSPDCVSS ASEATEAGQH
PGLAQNASGV SALSPQVAPS STESCFARQH NVSENNNQCF SGANGHLPSQ LAAQRPGAID
NQSLVNTDPM KAAPTLTLEG GRLKRSLQLV PGRDFETMPE PVWRALYHWY GANLSLPRPV
ILDSKTGQAE LELFPRYLLF LRQQPATRSP QSNIWVNMGM TTMRMFPPYM IPPRGSVPSP
NAPLKRVLAY TGCFSRVDTI KDIHLYLSQR LRIKEEDMRL WLFMSENYLT LLDDEDHTLE
NLKIQDEQQL VIEVRNKDMS WPEEMSFIAN SSKMDRHKVP TEKGATGLSN LGNTCFMNSS
IQCVSNTKPL TDYFLSGRHL YELNRTNPIG MRGHMAKCYG DLVMELWSGT QKSVAPLKLR
WTIAKYAPRF NGFQQQDSQE LLAFLLDGLH EDLNRVHEKP YVELKDSNGR PDWEVASEAW
ENHLRRNRSI VVDLFHGQLK SQVKCKTCGH ISARFDPFNF LSLPLPMDSY MHLEITVIKL
EGSTPVRYGL RLNMDEKYMG LKKQLSELCN LKPEQILLTE VHTSNIKNFP LDNQKVRLSV
NGFLCAFEIP VPGSPTSLSS PTLTGAADRP SLFLKFTSEM LLKMDSVKLA HLLSLDLTPI
ANGSAGGDNL TDNPALIPNG GPNTVVPCSP ETPVANGVAN GHATPVQESP FIGYIIAMHR
KMMRTELYFL SSQKNRPSLF GMPLIVPCTV HTTKKDLYDA VWIQVSRLAS PLPPQEASNH
AQDCDDSMGY QYPFTLRVVG KDGNTCAWCP WYRFCRGCVI ECTDDRASLG NAYIAVDWDP
TALHLRYQTS QERIVEEHCS VEQSRRAQAE PISLDSCLKA FTSEEELGED ELYYCSKCKT
HRLATKKLDL WRLPPILIVH LKRFQLVNGR WIKSQKIVKF PRENFDPSAF LAPRDLGQHC
LHSRSQSEDL LRVGEDNLSS VSAPAGLYNL PKVSPVICVT QSQSQRGSGL NLVVSPTASP
ATSRKSAPSL SRTSSPSGSP KSSSGGRRAA RLRLAKRSGK HWLSNSKENL DAAANPEADT
HAEAEAEAEA EAEAEAGAPL APGETTESPP SSHCDVVLLN GDSNGLSLDL STDSSLDPDA
SLLQHRGNTC LDAIYNLYAI SCHSGIMGGG HYVTYAKNPK KKWYCYNDSS CKEVQSEEID
ADSAYILFYE QQGVEYSHFL PQIDGKKMAD TSSMDEDFES DYKKYCVLQ
//